{"id":"tiapride","rwe":[{"pmid":"41887704","year":"2026","title":"[Volatile oil from Acorus tatarinowii Schott ameliorates tic disorder in rats by inhibiting TLR4/MyD88/NF-κB-mediated microglial polarization].","finding":"","journal":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","studyType":"Clinical Study"},{"pmid":"41880136","year":"2026","title":"Direct photolysis of tiapride in water: deep insights into desulfonation reaction.","finding":"","journal":"Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology","studyType":"Clinical Study"},{"pmid":"41687436","year":"2026","title":"Effect of pharmacological intervention and pathogenesis discussion about rats with tic disorders.","finding":"","journal":"Journal of neuroimmunology","studyType":"Clinical Study"},{"pmid":"41288886","year":"2025","title":"Elucidating the material basis and therapeutic mechanisms of Shaoma Zhijing granules for tourette syndrome by UPLC/Q-TOF-MS and multiple models.","finding":"","journal":"Metabolic brain disease","studyType":"Clinical Study"},{"pmid":"41220182","year":"2025","title":"Modulatory Effects of Jujuboside A on Amino Acid Neurotransmitter Profiles in Tic Disorder.","finding":"","journal":"Brain and behavior","studyType":"Clinical Study"}],"tags":[{"label":"tiapride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(4) dopamine receptor","category":"target"},{"label":"DRD4","category":"gene"},{"label":"DRD2","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"N05AL03","category":"atc"},{"label":"Active","category":"status"},{"label":"Antipsychotic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Dopamine Agents","category":"pharmacology"},{"label":"Dopamine Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"discontinued","safety":{"safetySignals":[{"llr":152.113,"date":"","count":54,"signal":"Extrapyramidal disorder","source":"DrugCentral FAERS","actionTaken":"Reported 54 times (LLR=152)"},{"llr":128.231,"date":"","count":49,"signal":"Neuroleptic malignant syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 49 times (LLR=128)"},{"llr":107.753,"date":"","count":51,"signal":"Altered state of consciousness","source":"DrugCentral FAERS","actionTaken":"Reported 51 times (LLR=108)"},{"llr":83.242,"date":"","count":84,"signal":"Somnolence","source":"DrugCentral FAERS","actionTaken":"Reported 84 times (LLR=83)"},{"llr":80.789,"date":"","count":31,"signal":"Parkinsonism","source":"DrugCentral FAERS","actionTaken":"Reported 31 times (LLR=81)"},{"llr":70.792,"date":"","count":39,"signal":"Dyskinesia","source":"DrugCentral FAERS","actionTaken":"Reported 39 times (LLR=71)"},{"llr":69.378,"date":"","count":86,"signal":"Confusional state","source":"DrugCentral FAERS","actionTaken":"Reported 86 times (LLR=69)"},{"llr":68.708,"date":"","count":50,"signal":"Coma","source":"DrugCentral FAERS","actionTaken":"Reported 50 times (LLR=69)"},{"llr":67.094,"date":"","count":106,"signal":"Fall","source":"DrugCentral FAERS","actionTaken":"Reported 106 times (LLR=67)"},{"llr":66.445,"date":"","count":22,"signal":"Hepatic fibrosis","source":"DrugCentral FAERS","actionTaken":"Reported 22 times (LLR=66)"},{"llr":55.097,"date":"","count":12,"signal":"Hepatic haematoma","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=55)"},{"llr":54.923,"date":"","count":85,"signal":"Drug interaction","source":"DrugCentral FAERS","actionTaken":"Reported 85 times (LLR=55)"},{"llr":54.19,"date":"","count":43,"signal":"Rhabdomyolysis","source":"DrugCentral FAERS","actionTaken":"Reported 43 times (LLR=54)"},{"llr":53.736,"date":"","count":37,"signal":"Pneumonia aspiration","source":"DrugCentral FAERS","actionTaken":"Reported 37 times (LLR=54)"},{"llr":47.78,"date":"","count":15,"signal":"Wrong patient received product","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=48)"}],"commonSideEffects":[{"effect":"Extrapyramidal disorder","drugRate":"LLR 152","severity":"common"},{"effect":"Neuroleptic malignant syndrome","drugRate":"LLR 128","severity":"common"},{"effect":"Altered state of consciousness","drugRate":"LLR 108","severity":"common"},{"effect":"Somnolence","drugRate":"LLR 83","severity":"common"},{"effect":"Parkinsonism","drugRate":"LLR 81","severity":"common"},{"effect":"Dyskinesia","drugRate":"LLR 71","severity":"common"},{"effect":"Confusional state","drugRate":"LLR 69","severity":"common"},{"effect":"Coma","drugRate":"LLR 69","severity":"common"},{"effect":"Fall","drugRate":"LLR 67","severity":"common"},{"effect":"Hepatic fibrosis","drugRate":"LLR 66","severity":"common"},{"effect":"Hepatic haematoma","drugRate":"LLR 55","severity":"common"},{"effect":"Drug interaction","drugRate":"LLR 55","severity":"common"},{"effect":"Rhabdomyolysis","drugRate":"LLR 54","severity":"common"},{"effect":"Pneumonia aspiration","drugRate":"LLR 54","severity":"common"},{"effect":"Wrong patient received product","drugRate":"LLR 48","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"thiapride","offLabel":[],"synonyms":["tiapridal","tiapride monohydrochloride","tiapride hydrochloride","tiapride","thiapride","tiaprizal","tiapride HCl"],"timeline":[],"approvals":[],"brandName":"Thiapride","ecosystem":[],"mechanism":{"target":"D(4) dopamine receptor, Alpha-2A adrenergic receptor, D(2) dopamine receptor","targets":[{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine 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When there's too much dopamine, it can cause problems like anxiety and agitation. Thiapride helps by blocking the D(4) dopamine receptor, which reduces the amount of dopamine that's active in the brain and helps to calm symptoms.","oneSentence":"Thiapride works by blocking the D(4) dopamine receptor, which helps to regulate mood and reduce symptoms of certain psychiatric conditions.","technicalDetail":"Thiapride acts as a selective antagonist at the D(4) dopamine receptor subtype, which is involved in the regulation of mood and emotional responses."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2651","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TIAPRIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TIAPRIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:53:33.029871","biosimilars":[],"competitors":[{"drugName":"amisulpride","drugSlug":"amisulpride","fdaApproval":"2020-02-26","patentExpiry":"Mar 10, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"tiapride","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"amisulpride","brandName":"amisulpride","genericName":"amisulpride","approvalYear":"2020","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02374567","phase":"PHASE3","title":"Pharmacovigilance in Gerontopsychiatric Patients","status":"TERMINATED","sponsor":"Hannover Medical School","startDate":"2015-01","conditions":["Dementia","Depression","Schizophrenia","Psychosomatic Disorders","Anxiety Disorders"],"enrollment":407,"completionDate":"2017-06-28"},{"nctId":"NCT00632645","phase":"PHASE3","title":"Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2009-04","conditions":["Huntington Disease"],"enrollment":180,"completionDate":"2017-04-28"},{"nctId":"NCT01765829","phase":"PHASE3","title":"Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis","status":"UNKNOWN","sponsor":"Fundación Pública Andaluza Progreso y Salud","startDate":"2012-11","conditions":["Psychosis Nos/Other"],"enrollment":104,"completionDate":"2015-11"},{"nctId":"NCT01501695","phase":"PHASE3","title":"Phase III Study of 5LGr to Treat Tic Disorder","status":"COMPLETED","sponsor":"Tasly Pharmaceuticals, Inc.","startDate":"2008-01","conditions":["Tic Disorder","Tourette Syndrome","Chronic Tic Disorder"],"enrollment":603,"completionDate":"2011-10"},{"nctId":"NCT00534573","phase":"PHASE3","title":"Benzamide Derivates as Treatment of Clozapine-induced Hypersalivation","status":"COMPLETED","sponsor":"Beersheva Mental Health Center","startDate":"2008-11","conditions":["Clozapine-induced Hypersalivation"],"enrollment":54,"completionDate":"2009-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"MMSL":"35065","NDDF":"005728","UNII":"LAH70H9JPH","CHEBI":"CHEBI:94666","INN_ID":"3289","RXNORM":"10588","UMLSCUI":"C3179399","ChEMBL_ID":"CHEMBL84158","KEGG_DRUG":"D01522","DRUGBANK_ID":"DB13025","PUBCHEM_CID":"5467","SECONDARY_CAS_RN":"51012-33-0","MESH_DESCRIPTOR_UI":"D063325"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"3.2 hours","clearance":"4.7 mL/min/kg","volumeOfDistribution":"1.1 L/kg"},"publicationCount":0,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05AL03","allCodes":["N05AL03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 20","pmid":"41887704","title":"[Volatile oil from Acorus tatarinowii Schott ameliorates tic disorder in rats by inhibiting TLR4/MyD88/NF-κB-mediated microglial polarization].","journal":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University"},{"date":"2026 Mar 25","pmid":"41880136","title":"Direct photolysis of tiapride in water: deep insights into desulfonation reaction.","journal":"Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology"},{"date":"2026 May","pmid":"41687436","title":"Effect of pharmacological intervention and pathogenesis discussion about rats with tic disorders.","journal":"Journal of neuroimmunology"},{"date":"2025 Nov 25","pmid":"41288886","title":"Elucidating the material basis and therapeutic mechanisms of Shaoma Zhijing granules for tourette syndrome by UPLC/Q-TOF-MS and multiple models.","journal":"Metabolic brain disease"},{"date":"2025 Nov","pmid":"41220182","title":"Modulatory Effects of Jujuboside A on Amino Acid Neurotransmitter Profiles in Tic Disorder.","journal":"Brain and behavior"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"discontinued","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thiapride (TIAPRIDE) is a small molecule drug that targets the D(4) dopamine receptor, classified as a tiapride. It is used to treat certain psychiatric conditions, although its exact approved indications are unknown. Thiapride's commercial status is unclear, with unknown patent status and generic manufacturers. The drug has a half-life of 3.2 hours, but its bioavailability is unknown. As a result, its availability and usage may be limited.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}