{"id":"thrombolysis-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding (major and minor)"},{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Reperfusion arrhythmias"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Thrombolytic agents work by converting plasminogen to plasmin, a serine protease that degrades fibrin—the structural protein in blood clots. This enzymatic fibrinolysis restores perfusion in thrombotic occlusions of coronary, cerebral, or peripheral vessels. The approach is time-sensitive and most effective when administered early after clot formation.","oneSentence":"Thrombolysis therapy dissolves blood clots by activating fibrinolytic enzymes to break down fibrin and restore blood flow in occluded vessels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:38:29.923Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute myocardial infarction"},{"name":"Acute ischemic stroke"},{"name":"Pulmonary embolism"},{"name":"Deep vein thrombosis"}]},"trialDetails":[{"nctId":"NCT07471256","phase":"PHASE3","title":"Neuronavigation-assisted Stereotactic Minimally Invasive Puncture With Tenecteplase for Acute Lobar Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-31","conditions":"Intracerebral Hemorrhage Lobar","enrollment":636},{"nctId":"NCT07294209","phase":"PHASE4","title":"Low-Dose Tenecteplase for Acute Ischemic Stroke Treatment in Aging Patients","status":"RECRUITING","sponsor":"Southwest Hospital, China","startDate":"2025-12-19","conditions":"Acute Ischemic Stroke Patients","enrollment":798},{"nctId":"NCT07469293","phase":"PHASE3","title":"Efficacy and Safety of Intra-arterial Tenecteplase in Acute Ischemic Stroke Patients With Medium Vessel Occlusion Stroke (DATE-MeVO)","status":"NOT_YET_RECRUITING","sponsor":"Southwest Hospital, China","startDate":"2026-03-25","conditions":"Acute Ischemic Stroke","enrollment":488},{"nctId":"NCT07203625","phase":"PHASE4","title":"Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours","status":"RECRUITING","sponsor":"Xuanwu Hospital, Beijing","startDate":"2026-01-20","conditions":"Acute Ischemic Stroke, Basilar Artery Occlusion","enrollment":316},{"nctId":"NCT07483281","phase":"NA","title":"Efficacy and Safety of Human Urinary Kallidinogenase Combined With Reteplase Intravenous Thrombolysis in the Treatment of Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"China-Japan Union Hospital","startDate":"2026-05-01","conditions":"Acute Ischemic Stroke","enrollment":220},{"nctId":"NCT06667999","phase":"PHASE4","title":"The Intensive Care Platform Trial","status":"RECRUITING","sponsor":"Anders Perner","startDate":"2025-06-26","conditions":"Intensive Care Patients, Intensive Care Unit Patients, Critical Illness","enrollment":10000},{"nctId":"NCT07237048","phase":"PHASE2, PHASE3","title":"Minocycline in Stroke Study at Maimonides","status":"RECRUITING","sponsor":"Joyce Chen","startDate":"2026-02-02","conditions":"Stroke, Ischemia Stroke, Hemorrhagic Strokes","enrollment":1164},{"nctId":"NCT06179017","phase":"NA","title":"Endovascular Treatment for Mild Stroke With Acute Anterior Circulation Large Vessel Occlusion","status":"RECRUITING","sponsor":"Zhangzhou Municipal Hospital","startDate":"2024-02-07","conditions":"Mild Stroke, Acute Ischemic Stroke, Endovascular Treatment","enrollment":300},{"nctId":"NCT07476898","phase":"PHASE3","title":"Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window","status":"NOT_YET_RECRUITING","sponsor":"First Hospital of China Medical University","startDate":"2026-03-01","conditions":"Stroke","enrollment":864},{"nctId":"NCT07452991","phase":"NA","title":"ULTRAsound-assisted Catheter-guided Thrombolysis for Intermediate-high Risk Patients With PE","status":"RECRUITING","sponsor":"National Medical Research Center for Cardiology, Ministry of Health of Russian Federation","startDate":"2024-09-10","conditions":"Pulmonary Embolism (PE)","enrollment":300},{"nctId":"NCT07475949","phase":"PHASE3","title":"Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital of Guangxi Medical University","startDate":"2026-04","conditions":"Acute Ischemic Stroke, Tenecteplase","enrollment":352},{"nctId":"NCT07475936","phase":"","title":"Intravenous Tenecteplase in Very Old Patients With Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital of Guangxi Medical University","startDate":"2026-04","conditions":"Acute Ischemic Stroke, Tenecteplase","enrollment":392},{"nctId":"NCT07471282","phase":"PHASE3","title":"Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy","status":"NOT_YET_RECRUITING","sponsor":"Chuansheng Zhao","startDate":"2026-03-01","conditions":"Stroke","enrollment":344},{"nctId":"NCT07460713","phase":"NA","title":"Advancing Reperfusion Therapy for Ischemic Stroke: Direct Transfer to Angiography Suite for Patients With Suspected Large Vessel Occlusion","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-31","conditions":"Ischemic Stroke, Large Vessel Occlusion","enrollment":568},{"nctId":"NCT06588634","phase":"NA","title":"The PERSEVERE Study","status":"RECRUITING","sponsor":"Inari Medical","startDate":"2024-12-16","conditions":"Pulmonary Embolism, Pulmonary Thromboembolism","enrollment":200},{"nctId":"NCT07187687","phase":"NA","title":"TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage","status":"RECRUITING","sponsor":"Xuanwu Hospital, Beijing","startDate":"2025-10-24","conditions":"Intracerebral Hemorrhage","enrollment":750},{"nctId":"NCT06975969","phase":"","title":"Single Center Post-Market Study of Thrombolytic Therapy Using the Versus™ Catheter","status":"WITHDRAWN","sponsor":"Liquet Medical Inc.","startDate":"2025-09-05","conditions":"Blood Clots, Vascular Disease, Embolism Thrombosis","enrollment":""},{"nctId":"NCT06018181","phase":"","title":"Outcomes After Intravenous Alteplase / Tenecteplase With or Without Shuxuetong Injection in Routine Clinical Practice","status":"COMPLETED","sponsor":"Dongzhimen Hospital, Beijing","startDate":"2023-09-28","conditions":"Ischemic Stroke, Acute","enrollment":2408},{"nctId":"NCT04973332","phase":"NA","title":"Safety and Efficacy of SINOMED SR for Endovascular Treatment of Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Sinomed Neurovita Technology Inc.","startDate":"2021-08-08","conditions":"Ischemic Stroke, Acute, Brain Diseases, Cerebrovascular Disorders","enrollment":218},{"nctId":"NCT06654453","phase":"NA","title":"The Thrombus Aspiration During PCI After Thrombolysis in STEMI","status":"RECRUITING","sponsor":"Shenghua Zhou","startDate":"2024-11-01","conditions":"ST-segment Elevation Myocardial Infarction","enrollment":3500},{"nctId":"NCT06124768","phase":"","title":"Comparison Of Percutaneous Mechanical Thrombectomy With Different Access in Treatment of Acute Deep Venous Thrombosis","status":"RECRUITING","sponsor":"RenJi Hospital","startDate":"2021-01-01","conditions":"Deep Vein Thrombosis","enrollment":210},{"nctId":"NCT07430917","phase":"PHASE2","title":"Safety and Efficacy of J147 in Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Abrexa Pharmaceuticals, Inc.","startDate":"2026-03-20","conditions":"Acute Ischemic Stroke","enrollment":196},{"nctId":"NCT06241677","phase":"NA","title":"Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on DOAC","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2024-04-15","conditions":"CVA (Cerebrovascular Accident)","enrollment":260},{"nctId":"NCT07424378","phase":"PHASE4","title":"Epoprostenol Plus Conventional Therapy in COld and Frostbite Injury (ECCO)","status":"NOT_YET_RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2026-02","conditions":"Frostbite","enrollment":66},{"nctId":"NCT07411079","phase":"","title":"Ex Vivo Reproduction of Minimally Invasive Surgery With Hematoma Lysis Using Modified Tissue Plasminogen Activator for Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Lille","startDate":"2026-02","conditions":"Intracerebral Hemorrhage, Hemorrhagic Risk Conditions, Bleeding Disorders","enrollment":1126},{"nctId":"NCT07323368","phase":"NA","title":"Advancing Reperfusion Therapy for Ischemic Stroke: Perfusion-guided Endovascular Intervention for Medium Vessel Occlusion Therapy","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-02-08","conditions":"Stroke Ischemic, Medium Vessel Occlusions","enrollment":568},{"nctId":"NCT07389460","phase":"PHASE3","title":"Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND)","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital Xi'an Jiaotong University","startDate":"2026-01-31","conditions":"Acute Ischemic Stroke","enrollment":820},{"nctId":"NCT07390032","phase":"NA","title":"The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion","status":"NOT_YET_RECRUITING","sponsor":"Feng Gao","startDate":"2026-03-01","conditions":"Acute Mild Basilar Artery Occlusion, Basilar Artery Occlusion, Endovascular Treatment","enrollment":230},{"nctId":"NCT07302971","phase":"NA","title":"Telemedicine-supported Management for Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Capital Medical University","startDate":"2026-02-02","conditions":"Acute Ischemic Stroke","enrollment":2400},{"nctId":"NCT07374978","phase":"NA","title":"Effect of Thrombolysis on 30-day Mortality in Intermediate High Risk Pulmonary Patients With Low Bleeding Risk","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-07-01","conditions":"Pulmonary Embolism Subacute Massive, Thrombolytic Therapy","enrollment":100},{"nctId":"NCT06486181","phase":"PHASE4","title":"Second Line Endovascular Treatment in Acute DVT","status":"NOT_YET_RECRUITING","sponsor":"Rush University Medical Center","startDate":"2026-04-01","conditions":"Deep Venous Thrombosis","enrollment":100},{"nctId":"NCT05911568","phase":"","title":"Treatment With Endovascular Intervention for STroke Patients With Existing Disability","status":"RECRUITING","sponsor":"University of Cincinnati","startDate":"2023-11-16","conditions":"Stroke, Stroke, Acute, Stroke, Ischemic","enrollment":1060},{"nctId":"NCT04663399","phase":"","title":"IMMunological resPonse Assessment afteR Acute iSchemic Stroke Treated With Endovascular Therapy (IMPRESS)","status":"RECRUITING","sponsor":"Fondation Ophtalmologique Adolphe de Rothschild","startDate":"2023-02-23","conditions":"Ischemic Stroke, Thrombectomy","enrollment":1200},{"nctId":"NCT07357987","phase":"PHASE3","title":"Intra-arterial Tenecteplase for Acute Medium Vessel Occlusion Stroke","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-01-22","conditions":"Ischemic Stroke, Medium Vessel Occlusion, Tenecteplase","enrollment":488},{"nctId":"NCT04785066","phase":"PHASE2","title":"Efficacy of Pulmozyme® on Arterial Recanalization in Post-thrombectomy Patients Managed for Ischemic Stroke (NETs-target)","status":"COMPLETED","sponsor":"Fondation Ophtalmologique Adolphe de Rothschild","startDate":"2022-08-19","conditions":"Ischemic Stroke","enrollment":39},{"nctId":"NCT06316570","phase":"PHASE3","title":"Ticagrelor With Aspirin Dual Antiplatelet Therapy Combined With Intravenous Thrombolysis for Ischemic Stroke","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2024-04-03","conditions":"Ischemic Stroke, Acute","enrollment":1382},{"nctId":"NCT07302854","phase":"PHASE2, PHASE3","title":"Intra-arterial Recombinant Human Tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Medium Vessel Occlusion","status":"RECRUITING","sponsor":"Xiang Luo","startDate":"2025-12-30","conditions":"Acute Ischemic Stroke, Medium Vessel Occlusion","enrollment":382},{"nctId":"NCT07003646","phase":"","title":"Reperfusion Treatment in Acute Pulmonary Embolism","status":"RECRUITING","sponsor":"Sahlgrenska University Hospital","startDate":"2025-04-01","conditions":"Pulmonary Embolism","enrollment":220},{"nctId":"NCT06949228","phase":"PHASE2, PHASE3","title":"Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial","status":"RECRUITING","sponsor":"ProMedica Health System","startDate":"2025-07-30","conditions":"Ischemic Stroke, Acute Disease","enrollment":132},{"nctId":"NCT07279259","phase":"PHASE2","title":"Thrombolysis in Early Acute Ischemic Stroke Trial-Blood Pressure Management","status":"RECRUITING","sponsor":"Shanghai East Hospital","startDate":"2026-01-15","conditions":"Stroke, Acute Ischemic Stroke, Thrombolysis","enrollment":340},{"nctId":"NCT07347626","phase":"PHASE3","title":"Eptifibatide for Extended Window Ischemic Stroke After Thrombolysis","status":"NOT_YET_RECRUITING","sponsor":"Xinqiao Hospital of Chongqing","startDate":"2026-03-01","conditions":"Acute Ischemic Stroke","enrollment":786},{"nctId":"NCT07336927","phase":"NA","title":"IAT-MeVO Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial","status":"NOT_YET_RECRUITING","sponsor":"Bo Wu","startDate":"2026-01-01","conditions":"Acute Ischemic Stroke Due to Medium-vessel-occlusion","enrollment":614},{"nctId":"NCT07333950","phase":"NA","title":"The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-01-01","conditions":"Acute Basilar Artery Occlusion, Endovascular Therapy, Large Core Infarction","enrollment":308},{"nctId":"NCT06904911","phase":"PHASE2","title":"Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy","status":"RECRUITING","sponsor":"University of Pennsylvania","startDate":"2025-12-11","conditions":"Acute Ischemic Stroke From Large Vessel Occlusion","enrollment":20},{"nctId":"NCT07322835","phase":"","title":"Efficacy and Safety of Reperfusion Therapy for Minor Ischemic Stroke in China","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital, Sun Yat-Sen University","startDate":"2026-01-01","conditions":"Minor Ischemic Stroke","enrollment":5400},{"nctId":"NCT07318948","phase":"NA","title":"BALANCE Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632","status":"NOT_YET_RECRUITING","sponsor":"Bo Wu","startDate":"2026-01-01","conditions":"Acute Ischemic Stroke","enrollment":1600},{"nctId":"NCT07316049","phase":"NA","title":"Construction and Evaluation of an Intelligent Decision System for Reperfusion Therapy in Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-12-15","conditions":"Acute Ischemic Stroke","enrollment":3000},{"nctId":"NCT00147316","phase":"PHASE3","title":"Japan Alteplase Clinical Trial (J-ACT): Efficacy and Safety Study of Tissue Plasminogen Activator (Alteplase) for Ischemic Stroke","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2002-04","conditions":"Cerebral Infarction, Brain Ischemia","enrollment":103},{"nctId":"NCT04434768","phase":"PHASE1","title":"Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Ischemic Stroke","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ever Supreme Bio Technology Co., Ltd.","startDate":"2020-12-02","conditions":"Acute Stroke","enrollment":10},{"nctId":"NCT06388148","phase":"NA","title":"Endovascular Treatment for eXtra-Large Ischemic Stroke","status":"RECRUITING","sponsor":"Zhongming Qiu","startDate":"2024-06-16","conditions":"Stroke, Acute Ischemic","enrollment":286},{"nctId":"NCT07301372","phase":"PHASE4","title":"Evaluation Study of Early Administration of Evolocumab After Thrombolysis in Patients With Atherosclerotic Acute Ischemic Stroke","status":"RECRUITING","sponsor":"The Affiliated Hospital of Xuzhou Medical University","startDate":"2025-10-30","conditions":"Acute Stroke","enrollment":132},{"nctId":"NCT05604638","phase":"PHASE3","title":"Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Second Affiliated Hospital of Guangxi Medical University","startDate":"2024-04-24","conditions":"Acute Ischemic Stroke","enrollment":348},{"nctId":"NCT07299994","phase":"","title":"Efficacy and Safety of Intravenous Thrombolysis in Branch Atheromatous Disease","status":"NOT_YET_RECRUITING","sponsor":"Sigmund Freud PrivatUniversitat","startDate":"2026-01-01","conditions":"Stroke, Thrombolysis, DAPT(Dual Antiplatelet Therapy)","enrollment":462},{"nctId":"NCT07290751","phase":"PHASE4","title":"Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Beijing Anzhen Hospital","startDate":"2025-11-11","conditions":"Acute Ischemic Stroke","enrollment":976},{"nctId":"NCT05152524","phase":"NA","title":"Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever","status":"ACTIVE_NOT_RECRUITING","sponsor":"Rapid Medical","startDate":"2022-03-25","conditions":"Ischemic Stroke, Neovascularization","enrollment":168},{"nctId":"NCT07241130","phase":"","title":"Using End-Tidal CO₂ to Help Diagnose and Monitor Pulmonary Embolism","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2025-02-01","conditions":"Pulmonary Embolism Acute","enrollment":120},{"nctId":"NCT06548971","phase":"PHASE3","title":"Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)","status":"RECRUITING","sponsor":"Capital Medical University","startDate":"2024-11-07","conditions":"Acute Ischemic Stroke, Cerebral Infarction","enrollment":1184},{"nctId":"NCT07201688","phase":"PHASE3","title":"Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.","status":"RECRUITING","sponsor":"CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.","startDate":"2025-11-30","conditions":"Acute Ischemic Stroke","enrollment":890},{"nctId":"NCT07137832","phase":"PHASE3","title":"OPtimizing REperfusion by Intra-Arterial ThRomboLysis as Adjunct to Endovascular Treatment for Medium Vessel Occlusion","status":"RECRUITING","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2025-10-09","conditions":"Acute Ischemic Stroke","enrollment":530},{"nctId":"NCT07269288","phase":"","title":"The Correlation and Mechanistic Study of GGCX Gene With Prognosis in Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Peking University Aerospace Center Hospital","startDate":"2026-01-25","conditions":"Acute Ischemic Stroke","enrollment":1500},{"nctId":"NCT06289985","phase":"NA","title":"StrokeNet Thrombectomy Endovascular Platform","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2025-01-31","conditions":"Ischemic Stroke","enrollment":1600},{"nctId":"NCT05752916","phase":"PHASE4","title":"Intravenous Thrombolysis With rhTNK-tPA for Acute Non-large Vessel Occlusion in Extended Time Window","status":"COMPLETED","sponsor":"Xuanwu Hospital, Beijing","startDate":"2023-06-02","conditions":"Acute Ischemic Stroke","enrollment":570},{"nctId":"NCT07208097","phase":"NA","title":"Stereotactic Thrombolysis With Tenecteplase for Supratentorial Intracerebral Hemorrhage","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2025-10-25","conditions":"Intracerebral Haemorrhage, Minimally Invasive Treatment","enrollment":768},{"nctId":"NCT05363397","phase":"PHASE2","title":"Safety and Tolerability of Adjunctive TBO-309 in Reperfusion for Stroke","status":"RECRUITING","sponsor":"The Florey Institute of Neuroscience and Mental Health","startDate":"2023-09-27","conditions":"Acute Ischemic Stroke","enrollment":80},{"nctId":"NCT05372718","phase":"PHASE3","title":"Thrombolysis With Recombinant Non-immunogenic Staphylokinase vs Surgery in Patients With Acute Limb Ischemia FORAT Trial","status":"RECRUITING","sponsor":"Supergene, LLC","startDate":"2022-12-26","conditions":"Acute Limb Ischemia","enrollment":170},{"nctId":"NCT07047326","phase":"NA","title":"Urokinase for Thrombolysis in Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Capital Medical University","startDate":"2025-10-01","conditions":"Acute Ischemic Stroke","enrollment":24},{"nctId":"NCT06221371","phase":"PHASE3","title":"Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2024-01-25","conditions":"Ischemic Stroke, Acute, Thrombolysis, Endovascular Treatment","enrollment":391},{"nctId":"NCT05631847","phase":"NA","title":"Direct Endovascular Treatment Versus Bridging Treatment In Basilar Artery Occlusive Stroke","status":"COMPLETED","sponsor":"Sichuan Academy of Medical Sciences","startDate":"2023-04-17","conditions":"Acute Ischemic Stroke, Basilar Artery Occlusion, Thrombosis","enrollment":345},{"nctId":"NCT03887143","phase":"","title":"National Retrospective Study Of Recanalization Treatments In Pediatric Arterial Ischemic Stroke","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-04-04","conditions":"Arterial Ischemic Stroke","enrollment":70},{"nctId":"NCT03957707","phase":"NA","title":"Sterotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2019-01-01","conditions":"Basal Ganglia Haematoma","enrollment":380},{"nctId":"NCT04526951","phase":"PHASE3","title":"TENecteplase in Central Retinal Artery Occlusion Stuy (TenCRAOS)","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2020-10-30","conditions":"Central Retinal Artery Occlusion","enrollment":81},{"nctId":"NCT07185022","phase":"NA","title":"Intra-arterial Thrombolysis for Acute Ischemic Stroke With Medium Vessel Occlusion","status":"NOT_YET_RECRUITING","sponsor":"The Second Hospital of Anhui Medical University","startDate":"2025-10-01","conditions":"Stroke, Cerebrovascular Disorders, Brain Diseases","enrollment":282},{"nctId":"NCT05797792","phase":"PHASE3","title":"CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital Clinic of Barcelona","startDate":"2023-11-18","conditions":"Stroke, Acute Ischemic, Stroke, Acute","enrollment":440},{"nctId":"NCT04861506","phase":"","title":"The Safety and Efficiency of Endovascular Treatment of Acute or Subacute Thromboembolic Occlusions of Lower Extremity.","status":"RECRUITING","sponsor":"First People's Hospital of Hangzhou","startDate":"2021-04-01","conditions":"Thromboembolic Disease, Lower Extremity Problem, Endovascular Treatment","enrollment":400},{"nctId":"NCT06155032","phase":"NA","title":"Rescue Endovascular Therapy for Progressive Acute Mild Ischemic Stroke With Large Vascular Occlusion","status":"RECRUITING","sponsor":"First Affiliated Hospital of Wannan Medical College","startDate":"2024-01-04","conditions":"Stroke, Ischemic, Cerebrovascular; Disorder, Occlusive","enrollment":272},{"nctId":"NCT06638151","phase":"PHASE2","title":"Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime)","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2025-09-02","conditions":"Acute Ischemic Stroke","enrollment":200},{"nctId":"NCT07151755","phase":"NA","title":"Microneedle Intra-Arterial Injection for Retinal Artery Occlusion","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-09-01","conditions":"Central Retinal Artery Occlusion","enrollment":24},{"nctId":"NCT06878066","phase":"PHASE3","title":"Thrombolysis in Factor Xa-inhibitors Trial","status":"RECRUITING","sponsor":"Guri Hagberg","startDate":"2025-03-14","conditions":"Stroke, Stroke (in Patients With Atrial Fibrillation), Ischemic Stroke","enrollment":300},{"nctId":"NCT06530927","phase":"","title":"Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure","status":"RECRUITING","sponsor":"University of Zurich","startDate":"2025-02-01","conditions":"Ischemic Stroke","enrollment":500},{"nctId":"NCT07146360","phase":"PHASE3","title":"Efficacy and Safety Study of Proposed Biosimilar Product Reveliza vs Actilise in Patients With ST-segment Elevation Myocardial Infarction","status":"COMPLETED","sponsor":"AO GENERIUM","startDate":"2014-05-25","conditions":"Myocardial Infarction (MI)","enrollment":180},{"nctId":"NCT06094478","phase":"NA","title":"Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2024-10-17","conditions":"Stroke, Acute, Ischemic Stroke, Acute, Hemorrhagic Stroke","enrollment":900},{"nctId":"NCT05644925","phase":"NA","title":"Effects of Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) Therapy on miRNAs Expression and Absolute Microvascular Resistance by Continuous Thermodilution in ST-segment Elevation Myocardial Infarction (STEMI) Patients: PiCSO-STEMI TRIAL","status":"WITHDRAWN","sponsor":"Fundacio Privada Mon Clinic Barcelona","startDate":"2022-11-14","conditions":"Anterior Myocardial Infarction","enrollment":""},{"nctId":"NCT05897554","phase":"NA","title":"Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)","status":"COMPLETED","sponsor":"Xuanwu Hospital, Beijing","startDate":"2023-08-11","conditions":"Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction","enrollment":247},{"nctId":"NCT07119021","phase":"PHASE4","title":"Efficacy and Safety Study of Ultra-early Mobile Stroke Unit Neuroprotection Combined With Revascularization for Acute Ischemic Stroke (EXCELLENT)","status":"RECRUITING","sponsor":"Ruijun Ji","startDate":"2024-08-01","conditions":"Ischemic Stroke","enrollment":300},{"nctId":"NCT06052969","phase":"NA","title":"Pulse Endovascular ReperFUSION for Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Euphrates Vascular, Inc.","startDate":"2023-10-01","conditions":"Acute Ischemic Stroke AIS, Cerebral Arterial Disease","enrollment":8},{"nctId":"NCT06440707","phase":"PHASE2","title":"Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke","status":"RECRUITING","sponsor":"University of California, Los Angeles","startDate":"2025-07-15","conditions":"Acute Ischemic Stroke","enrollment":120},{"nctId":"NCT07092904","phase":"","title":"Myocardial Infarction Safe Emergency Medicine Accompanying Study: Providing Reperfusion Therapy Within the Recommended Time Limits","status":"NOT_YET_RECRUITING","sponsor":"University Hospital of North Norway","startDate":"2025-09-01","conditions":"Infarction","enrollment":200},{"nctId":"NCT07094763","phase":"NA","title":"Efficacy and Safety of Tenecteplase Intravenous Thrombolysis in Acute Posterior Circulation Ischemic Stroke Within 4.5-24 Hours After Onset","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of University of Science and Technology of China","startDate":"2025-08-05","conditions":"Acute Ischemic Stroke","enrollment":406},{"nctId":"NCT07090941","phase":"NA","title":"EVT in Acute Basilar Artery Occlusion With Large Infarction Core","status":"RECRUITING","sponsor":"The First Affiliated Hospital of Hainan Medical University","startDate":"2025-08-01","conditions":"Basilar Artery Occlusion, Large Ischemic Core, Large Core Infarct","enrollment":348},{"nctId":"NCT05892510","phase":"PHASE2, PHASE3","title":"Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke","status":"RECRUITING","sponsor":"University of Melbourne","startDate":"2024-06-01","conditions":"Ischemic Stroke, Acute, Cerebrovascular Disorders, Brain Disorder","enrollment":462},{"nctId":"NCT04920448","phase":"PHASE2","title":"N-ACETYLCYSTEINE FOR THROMBOLYSIS IN ACUTE STROKE","status":"TERMINATED","sponsor":"University Hospital, Caen","startDate":"2021-06-16","conditions":"Stroke, Ischemic","enrollment":12},{"nctId":"NCT06157502","phase":"PHASE3","title":"Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY)","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2024-01-11","conditions":"Ischemic Stroke, Acute","enrollment":1380},{"nctId":"NCT06414499","phase":"PHASE3","title":"Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-07-09","conditions":"Minor Ischemic Stroke","enrollment":1386},{"nctId":"NCT05990894","phase":"","title":"Steroid for Treatment of Acute/Subacute Severe Cerebral Venous Thrombosis.","status":"COMPLETED","sponsor":"Xuanwu Hospital, Beijing","startDate":"2020-07-01","conditions":"Cerebral Venous Thrombosis","enrollment":170},{"nctId":"NCT07046299","phase":"NA","title":"Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct","status":"NOT_YET_RECRUITING","sponsor":"Capital Medical University","startDate":"2025-07-01","conditions":"Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct","enrollment":314},{"nctId":"NCT03971500","phase":"NA","title":"1-month vs 12-month DAPT for ACS Patients Who Underwent PCI Stratified by IVUS: IVUS-ACS and ULTIMATE-DAPT Trials","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2019-08-20","conditions":"Coronary Artery Disease","enrollment":3710},{"nctId":"NCT06941753","phase":"NA","title":"Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge","status":"RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-06-20","conditions":"Stroke, Acute, Educational Problems, Clinical Course","enrollment":22},{"nctId":"NCT07032025","phase":"EARLY_PHASE1","title":"Mechanical Thrombectomy for Acute Pulmonary Embolism","status":"NOT_YET_RECRUITING","sponsor":"RenJi Hospital","startDate":"2025-07-01","conditions":"Acute Pulmonary Embolism","enrollment":200},{"nctId":"NCT05591118","phase":"PHASE3","title":"Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2023-07-17","conditions":"Pulmonary Embolism","enrollment":500},{"nctId":"NCT07029841","phase":"","title":"Cohort Study on Treatment Comes of Catheter-based Therapy in Patients With Acute Pulmonary Embolism in Hong Kong","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2022-06-01","conditions":"Pulmonary Embolism Acute, Pulmonary Embolism Acute Massive, Pulmonary Embolism Subacute Massive","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":367,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["systemic thrombolysis","full-dose systemic thrombolysis","thrombolysis","thrombolytic therapy","Alteplase"],"phase":"phase_3","status":"active","brandName":"thrombolysis therapy","genericName":"thrombolysis therapy","companyName":"Leiden University Medical Center","companyId":"leiden-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thrombolysis therapy involves administering alteplase, a recombinant tissue plasminogen activator, to dissolve blood clots in conditions such as acute ischemic stroke and large vessel occlusion. Alteplase is administered via a 10% IV bolus followed by a 90% 1-hour IV drip at a dose of 0.9mg/kg.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}