{"id":"thrombin-jmi","safety":{"commonSideEffects":[{"rate":null,"effect":"Thrombosis (when absorbed systemically)"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":{"setId":"ba8fcebf-a924-488f-983d-088892761f0e","title":"THROMBIN-JMI (THROMBIN, TOPICAL (BOVINE)) KIT [PFIZER LABORATORIES DIV PFIZER INC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Thrombin JMI is a serine protease derived from bovine sources that catalyzes the final step of the coagulation cascade by cleaving fibrinogen into fibrin monomers, which polymerize to form a stable clot. It is applied topically to surgical wounds and bleeding sites to achieve rapid hemostasis without requiring the upstream coagulation cascade. This allows for immediate clot formation at the site of application.","oneSentence":"Thrombin JMI is a topical thrombin preparation that directly converts fibrinogen to fibrin to promote blood clotting and hemostasis at wound sites.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:12:30.902Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis in surgical procedures"},{"name":"Control of bleeding in general surgery, cardiac surgery, and vascular surgery"}]},"trialDetails":[{"nctId":"NCT05124041","phase":"NA","title":"Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2021-11-15","conditions":"Acute on Chronic Liver Failure, Variceal Hemorrhage, Cirrhosis, Liver","enrollment":262},{"nctId":"NCT07101926","phase":"","title":"Monitoring of Anti-TFPI in 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