{"id":"thioglycolic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Chemical burn"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Thioglycolic acid works by cleaving the disulfide bonds (S-S linkages) that cross-link and stabilize the keratin protein structure in hair. This chemical reduction weakens the hair shaft, causing it to soften and dissolve, allowing it to be wiped away. The mechanism is pH-dependent and requires an alkaline environment (typically provided by calcium thioglycollate formulations) to be effective.","oneSentence":"Thioglycolic acid is a reducing agent that breaks disulfide bonds in keratin, softening and dissolving hair for depilation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:12:28.557Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hair removal / depilation"}]},"trialDetails":[{"nctId":"NCT02219295","phase":"NA","title":"SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition","status":"COMPLETED","sponsor":"German Institute of Human Nutrition","startDate":"2011-12","conditions":"Disorder of Glucose Regulation","enrollment":97},{"nctId":"NCT03238105","phase":"PHASE4","title":"Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light","status":"UNKNOWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2017-08-01","conditions":"Periorbital Disorder","enrollment":29}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":919,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Thioglycolic Acid","genericName":"Thioglycolic Acid","companyName":"Hospital de Clinicas de Porto Alegre","companyId":"hospital-de-clinicas-de-porto-alegre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thioglycolic acid is a reducing agent that breaks disulfide bonds in keratin, softening and dissolving hair for depilation. Used for Hair removal / depilation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}