{"id":"thiocolchicoside-ketoprofen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances (nausea, dyspepsia)"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Thiocolchicoside is a semi-synthetic derivative of colchicoside that acts as a muscle relaxant by enhancing GABAergic neurotransmission in the central nervous system, thereby reducing muscle tone and spasticity. Ketoprofen is a non-selective NSAID that inhibits COX-1 and COX-2, reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever. The combination provides complementary analgesic and anti-inflammatory effects for musculoskeletal conditions.","oneSentence":"Thiocolchicoside reduces muscle spasticity through GABA-A receptor modulation, while ketoprofen inhibits cyclooxygenase enzymes to reduce inflammation and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:38:32.978Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute musculoskeletal pain and spasticity"},{"name":"Muscle contractures and spasticity associated with neurological conditions"}]},"trialDetails":[{"nctId":"NCT00679146","phase":"PHASE3","title":"Efficacy Safety of a Combination Thiocolchicoside+Ketoprofen Compared to Thiocolchicoside Twice a Day for 7 Days in Patients Suffering From Acute Non Specific Low Back Pain","status":"COMPLETED","sponsor":"Sanofi","startDate":"2008-04","conditions":"Low Back Pain","enrollment":334}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Thiocolchicoside+Ketoprofen","genericName":"Thiocolchicoside+Ketoprofen","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thiocolchicoside+Ketoprofen is a fixed combination of two small molecule compounds used to treat acute non-specific low back pain. It is a small molecule modality that has been studied for its efficacy and safety in clinical trials, specifically for low back pain.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}