{"id":"tetrastarch-voluven","safety":{"commonSideEffects":[{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy / increased bleeding"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tetrastarch (hydroxyethyl starch, HES) is a branched polysaccharide derived from amylopectin that functions as a plasma volume expander. It remains in the intravascular space longer than crystalloid solutions, providing sustained hemodynamic support. The molecule's structure allows it to exert oncotic pressure, drawing and retaining fluid within blood vessels to maintain circulating volume.","oneSentence":"Tetrastarch is a synthetic colloid that expands intravascular volume by osmotically retaining fluid in the bloodstream.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:12:01.861Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss and hypovolemia requiring volume replacement in surgical and trauma patients"}]},"trialDetails":[{"nctId":"NCT01652131","phase":"NA","title":"Behaviour of Intravenous Solutions in Obese Patients Under General Anesthesia","status":"UNKNOWN","sponsor":"National Institute of Medical Sciences and Nutrition, Salvador Zubiran","startDate":"2012-05","conditions":"Obesity, Obesity, Morbid","enrollment":12},{"nctId":"NCT00890383","phase":"PHASE4","title":"Colloids in Severe Trauma","status":"COMPLETED","sponsor":"University of the Philippines","startDate":"2009-05","conditions":"Abdominal Hypertension, Abdominal Compartment Syndrome, Severe Trauma","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Voluven"],"phase":"marketed","status":"active","brandName":"tetrastarch (Voluven)","genericName":"tetrastarch (Voluven)","companyName":"University of the Philippines","companyId":"university-of-the-philippines","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tetrastarch is a synthetic colloid that expands intravascular volume by osmotically retaining fluid in the bloodstream. Used for Acute blood loss and hypovolemia requiring volume replacement in surgical and trauma patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}