{"id":"tetraspan-b-braun-melsungen-germany","safety":{"commonSideEffects":[{"rate":null,"effect":"Coagulopathy / increased bleeding risk"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL692","moleculeType":"Small molecule","molecularWeight":"92.09"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tetraspan is a balanced hydroxyethyl starch (HES) solution designed to restore and maintain circulating blood volume in hypovolemic patients. It works through osmotic pressure to draw and retain fluid in the intravascular space, thereby improving tissue perfusion and oxygen delivery. The balanced electrolyte formulation aims to minimize electrolyte disturbances compared to older HES formulations.","oneSentence":"Tetraspan is a synthetic colloid plasma expander that increases and maintains intravascular volume by osmotic effect.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:11:56.860Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypovolemia and volume replacement in surgical and trauma patients"},{"name":"Perioperative fluid management"}]},"trialDetails":[{"nctId":"NCT01670604","phase":"PHASE4","title":"Use of Two Modern Hydroxyethyl Starch Solutions in Major Urological Procedures","status":"UNKNOWN","sponsor":"Kasr El Aini Hospital","startDate":"2012-01","conditions":"Urologic Surgical Procedures","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tetraspan, B. Braun, Melsungen, Germany","genericName":"Tetraspan, B. Braun, Melsungen, Germany","companyName":"Kasr El Aini Hospital","companyId":"kasr-el-aini-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tetraspan is a synthetic colloid plasma expander that increases and maintains intravascular volume by osmotic effect. Used for Hypovolemia and volume replacement in surgical and trauma patients, Perioperative fluid management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}