{"id":"tetracycline-bq10","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Photosensitivity"},{"rate":"5-15","effect":"Nausea and vomiting"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"1-5","effect":"Esophageal irritation"},{"rate":null,"effect":"Tooth discoloration (in children)"},{"rate":"1-5","effect":"Vaginal candidiasis"}]},"_chembl":{"chemblId":"CHEMBL454950","moleculeType":"Small molecule","molecularWeight":"480.90"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tetracycline is a broad-spectrum antibiotic that binds reversibly to the bacterial 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the A site of the ribosome. This inhibits peptide chain elongation and prevents bacterial protein synthesis. It is bacteriostatic, meaning it stops bacterial growth rather than directly killing the organisms.","oneSentence":"Tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:11:55.454Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections susceptible to tetracycline (e.g., respiratory tract infections, urinary tract infections, skin infections)"},{"name":"Acne vulgaris"},{"name":"Rickettsial infections"},{"name":"Chlamydial infections"}]},"trialDetails":[{"nctId":"NCT03208426","phase":"PHASE4","title":"Sequential Versus Quadruple Therapy in the Second-line Treatment","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2017-10-01","conditions":"Helicobacter Pylori Infection","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tetracycline Capsule"],"phase":"marketed","status":"active","brandName":"tetracycline (BQ10)","genericName":"tetracycline (BQ10)","companyName":"National Taiwan University Hospital","companyId":"national-taiwan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation. Used for Bacterial infections susceptible to tetracycline (e.g., respiratory tract infections, urinary tract infections, skin infections), Acne vulgaris, Rickettsial infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}