{"id":"tetracaine-hydrochloride-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Systemic toxicity (if absorbed in large amounts)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an ester-type local anesthetic, tetracaine works by inhibiting sodium influx through voltage-gated sodium channels in neuronal membranes, thereby stabilizing the membrane and preventing depolarization. This action reversibly blocks pain sensation and other nerve conduction in the area where applied. The gel formulation allows topical delivery for surface anesthesia of mucous membranes and skin.","oneSentence":"Tetracaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:12:00.381Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia of mucous membranes and skin"},{"name":"Surface anesthesia prior to minor procedures"}]},"trialDetails":[{"nctId":"NCT05557721","phase":"","title":"Uddevalla Skövde Transscleral Micropulse Study","status":"ENROLLING_BY_INVITATION","sponsor":"Vastra Gotaland Region","startDate":"2023-10-06","conditions":"Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma","enrollment":40},{"nctId":"NCT03749915","phase":"NA","title":"Ametop Compared to Ametop With Pain Ease Spray","status":"UNKNOWN","sponsor":"University of British Columbia","startDate":"2018-11-20","conditions":"Analgesia, Topical Anesthetic","enrollment":240},{"nctId":"NCT02955524","phase":"EARLY_PHASE1","title":"Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma","status":"WITHDRAWN","sponsor":"University of Miami","startDate":"2018-03","conditions":"Hemodynamic Instability","enrollment":""},{"nctId":"NCT02863679","phase":"NA","title":"Postoperative Analgesic Efficacy of Tetracaine Hydrochloride Gel","status":"COMPLETED","sponsor":"Wenzhou Medical University","startDate":"2016-05","conditions":"Hysteroscopy","enrollment":84},{"nctId":"NCT01640171","phase":"NA","title":"Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival","status":"COMPLETED","sponsor":"Retina Vitreous Associates of Florida","startDate":"2012-07","conditions":"Age-related Macular Degeneration, Central Retinal Vein Occlusion, Diabetic Macular Edema","enrollment":57}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tetracaine HCL"],"phase":"marketed","status":"active","brandName":"Tetracaine hydrochloride gel","genericName":"Tetracaine hydrochloride gel","companyName":"Wenzhou Medical University","companyId":"wenzhou-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tetracaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia of mucous membranes and skin, Surface anesthesia prior to minor procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}