{"id":"tetanus-diphteria","safety":{"commonSideEffects":[{"rate":"20-50","effect":"Injection site pain, redness, or swelling"},{"rate":"5-15","effect":"Fever"},{"rate":"5-10","effect":"Myalgia"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL2108107","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tetanus-diphtheria (Td) vaccine contains inactivated toxoids from Clostridium tetani and Corynebacterium diphtheriae. These toxoids are chemically inactivated bacterial toxins that trigger B-cell and T-cell responses without causing disease. The resulting antibodies neutralize the actual toxins produced during natural infection, preventing tetanus and diphtheria.","oneSentence":"This vaccine stimulates the immune system to produce antibodies against tetanus toxin and diphtheria toxin, providing active immunization against both diseases.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:11:50.323Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Active immunization against tetanus and diphtheria in adolescents and adults"},{"name":"Booster vaccination for tetanus and diphtheria protection"}]},"trialDetails":[{"nctId":"NCT02140047","phase":"PHASE2","title":"Exploratory Clinical Study of MT-2301","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2014-04","conditions":"Haemophilus Influenza Type b","enrollment":154},{"nctId":"NCT02992925","phase":"PHASE3","title":"Phase 3 Study of BK1310 in Healthy Infants","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2016-11","conditions":"Immunization; Infection","enrollment":370},{"nctId":"NCT03519373","phase":"","title":"Pertussis Immunization During Pregnancy & HIV Infection","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Saint Pierre","startDate":"2017-03-01","conditions":"Immunization; Infection, Pertussis, HIV-1-infection","enrollment":135},{"nctId":"NCT03180359","phase":"NA","title":"Vaccines Immunogenicity in Renal, Hepatic, Cardiac or Pulmonary Transplanted Children","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2016-01-01","conditions":"Transplantation","enrollment":55},{"nctId":"NCT00148941","phase":"PHASE3","title":"Immune Response and Safety Comparison of 3 Lots of GSK Biologicals' DTaP-IPV Candidate Vaccine to DTaP + IPV Vaccines","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-01-06","conditions":"Tetanus, Acellular Pertussis, Diphtheria","enrollment":4209},{"nctId":"NCT03587610","phase":"NA","title":"Evaluation of a Tdap-IPV (Tetanus, Diphteria, Pertussis and Inactivated Polio) Vaccination Remedial Strategy on Vaccination Coverage in Patients 65 Years of Age or Older","status":"UNKNOWN","sponsor":"Centre Hospitalier le Mans","startDate":"2018-05-24","conditions":"Vaccination","enrollment":402},{"nctId":"NCT03402776","phase":"PHASE3","title":"Impact of a Fourth Hexavalent Vaccine After Hematopoietic Stem Cell Transplantation","status":"UNKNOWN","sponsor":"University Hospital, Grenoble","startDate":"2018-05-01","conditions":"Haemopoietic Stem Cell Transplantation, Allograft","enrollment":200},{"nctId":"NCT01249183","phase":"PHASE3","title":"Safety and Immunogenicity Study of Concomitant Versus Non Concomitant Administration of a Diphtheria, Tetanus, Pertussis and Poliomyelitis Vaccine (REPEVAX) and Influenza Vaccine (VAXIGRIP) in Subjects Aged From 60 Years Old","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2010-10","conditions":"Diphtheria, Tetanus, Pertussis","enrollment":954},{"nctId":"NCT00158808","phase":"PHASE2","title":"Immune Memory Foll Pry Vaccination With DTPw-HBV/Hib Vaccine Formulation; Immuno & Reacto of Booster Dose at 15-18 Mths","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-01","conditions":"Hib Disease, Hepatitis B, Pertussis","enrollment":175},{"nctId":"NCT00258908","phase":"PHASE3","title":"Immunogenicity and Safety of ADACEL™ as Fifth Dose in Taiwan","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2005-11","conditions":"Diphtheria, Tetanus, Pertussis","enrollment":115},{"nctId":"NCT01529645","phase":"PHASE1","title":"Safety and Dose Ranging Study of Acellular Pertussis and Acellular Pertussis -Tetanus-Diphtheria Booster Vaccines in Healthy Adults Ages 18 to 40 Years","status":"COMPLETED","sponsor":"Novartis Vaccines","startDate":"2012-03","conditions":"Pertussis, Whooping Cough, Tetanus","enrollment":420},{"nctId":"NCT02382913","phase":"PHASE1","title":"Persistency Study After aP / Tdap Booster Vaccines in Adult Subjects (V113_01 Extension 1)","status":"COMPLETED","sponsor":"Novartis","startDate":"2015-04","conditions":"Pertussis","enrollment":315},{"nctId":"NCT01986335","phase":"PHASE3","title":"Protectivity and Safety of DTP/HB/Hib (Bio Farma) Vaccines in Infants, Batch Consistency, Multi Center Trial","status":"COMPLETED","sponsor":"PT Bio Farma","startDate":"2012-08","conditions":"Healthy","enrollment":600},{"nctId":"NCT01986322","phase":"PHASE2","title":"Immunogenicity and Safety of DTP/HB/Hib (Bio Farma)Compared to DTP/HB Given Simultaneously With Hib(Registered)Vaccine","status":"COMPLETED","sponsor":"PT Bio Farma","startDate":"2011-07","conditions":"Healthy","enrollment":220},{"nctId":"NCT01977196","phase":"PHASE1","title":"The Safety and Immunogenicity of DTP/Hepatitis B 10ug Hib Vaccine (Bio Farma)","status":"COMPLETED","sponsor":"PT Bio Farma","startDate":"2011-04","conditions":"Healthy","enrollment":30},{"nctId":"NCT00453570","phase":"PHASE3","title":"Immunogenicity and Safety of Pentaxim as 3 Doses Primary Vaccination Followed by a Booster Dose at 18 Months","status":"COMPLETED","sponsor":"Sanofi","startDate":"2007-03","conditions":"Diphtheria, Tetanus, Haemophilus Influenzae Type b","enrollment":792},{"nctId":"NCT00254969","phase":"PHASE3","title":"Immunogenicity and Safety of Pentaxim in South African Infants","status":"COMPLETED","sponsor":"Sanofi","startDate":"2005-10","conditions":"Diphtheria, Tetanus, Haemophilus Infections","enrollment":212},{"nctId":"NCT00254917","phase":"PHASE4","title":"Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines","status":"COMPLETED","sponsor":"Sanofi","startDate":"2003-10","conditions":"Diphtheria, Tetanus, Polio","enrollment":387},{"nctId":"NCT00319852","phase":"PHASE3","title":"Immunogenicity and Safety of Tetraxim Versus Local DTP + IPV","status":"COMPLETED","sponsor":"Sanofi","startDate":"2006-04","conditions":"Pertussis, Diphtheria, Poliomyelitis","enrollment":442},{"nctId":"NCT00255021","phase":"PHASE4","title":"Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand","status":"COMPLETED","sponsor":"Sanofi","startDate":"2005-12","conditions":"Diphtheria, Tetanus, Poliomyelitis","enrollment":186},{"nctId":"NCT00259337","phase":"PHASE3","title":"Immunogenicity and Safety of Pentaxim™ in an Indian Population","status":"COMPLETED","sponsor":"Sanofi","startDate":"2006-02","conditions":"Diphtheria, Tetanus, Polio","enrollment":226},{"nctId":"NCT00244673","phase":"PHASE4","title":"Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination","status":"COMPLETED","sponsor":"Bandim Health Project","startDate":"2005-10","conditions":"Mortality, Hospitalization, Adverse Events","enrollment":6534},{"nctId":"NCT00514059","phase":"PHASE4","title":"Immunogenicity and Safety Study of a Booster Dose (5th) of Diphteria-Tetanus-Pertussis-Polio Vaccine","status":"COMPLETED","sponsor":"Norwegian Institute of Public Health","startDate":"2007-04","conditions":"Diphtheria, Tetanus, Pertussis","enrollment":83},{"nctId":"NCT00329251","phase":"PHASE4","title":"Study of the Influence of Vaccination in HIV Viral Load and Immunologic Responses Against HIV","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2003-04","conditions":"HIV","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tetanus-diphteria","genericName":"Tetanus-diphteria","companyName":"Hospital Clinic of Barcelona","companyId":"hospital-clinic-of-barcelona","modality":"Biologic","firstApprovalDate":"","aiSummary":"This vaccine stimulates the immune system to produce antibodies against tetanus toxin and diphtheria toxin, providing active immunization against both diseases. Used for Active immunization against tetanus and diphtheria in adolescents and adults, Booster vaccination for tetanus and diphtheria protection.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}