{"id":"testosterone-undecanoate-plus-letrozole","safety":{"commonSideEffects":[{"rate":"null","effect":"Hot flashes"},{"rate":"null","effect":"Vaginal bleeding"},{"rate":"null","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2107067","moleculeType":"Small molecule","molecularWeight":"456.71"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Testosterone undecanoate works by increasing the levels of testosterone in the body, which can help alleviate symptoms of low testosterone. Letrozole, on the other hand, inhibits the production of estrogen, which can help reduce the risk of estrogen-related side effects and improve the effectiveness of testosterone therapy.","oneSentence":"Testosterone undecanoate increases testosterone levels, while letrozole inhibits estrogen production, potentially treating conditions associated with hormonal imbalance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:38:09.347Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of low testosterone in men"}]},"trialDetails":[{"nctId":"NCT00146146","phase":"PHASE3","title":"Testosterone and Its Metabolites in GID","status":"COMPLETED","sponsor":"Unita Complessa di Ostetricia e Ginecologia","startDate":"2005-05","conditions":"Transsexualism","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nebid"],"phase":"phase_3","status":"active","brandName":"testosterone undecanoate plus letrozole","genericName":"testosterone undecanoate plus letrozole","companyName":"Unita Complessa di Ostetricia e Ginecologia","companyId":"unita-complessa-di-ostetricia-e-ginecologia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Testosterone undecanoate is a small molecule androgen receptor agonist used to treat conditions such as transsexualism. When combined with letrozole, a medication that inhibits aromatase, testosterone undecanoate may be used to treat transsexualism, although the exact mechanism of this combination is not specified.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}