{"id":"testosterone-pellet-100-mg","safety":{"commonSideEffects":[{"rate":null,"effect":"Polycythemia"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Injection site reaction"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Prostate-related symptoms"}]},"_chembl":{"chemblId":"CHEMBL1200335","moleculeType":"Small molecule","molecularWeight":"400.60"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"The subcutaneous pellet formulation provides continuous testosterone release over several months, bypassing first-pass hepatic metabolism and maintaining stable serum levels. This restores androgen-dependent physiological functions including muscle mass, bone density, sexual function, and mood regulation in testosterone-deficient individuals.","oneSentence":"Testosterone pellet delivers sustained testosterone replacement to restore physiological hormone levels in hypogonadal patients.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:38:08.671Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypogonadism (testosterone deficiency)"},{"name":"Age-related testosterone decline"}]},"trialDetails":[{"nctId":"NCT06343870","phase":"PHASE3","title":"Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)","status":"RECRUITING","sponsor":"University of Sao Paulo General Hospital","startDate":"2025-12-18","conditions":"Menopause, Testosterone Deficiency, Estrogen Deficiency","enrollment":140},{"nctId":"NCT04523480","phase":"PHASE3","title":"Testopel ® vs. Generic Testosterone Pellets.","status":"COMPLETED","sponsor":"University of Miami","startDate":"2020-03-12","conditions":"Hypogonadism","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["testosterone subdermal implant"],"phase":"phase_3","status":"active","brandName":"testosterone pellet (100 mg)","genericName":"testosterone pellet (100 mg)","companyName":"University of Sao Paulo General Hospital","companyId":"university-of-sao-paulo-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A 100 mg testosterone pellet is a long-acting subcutaneous implant that acts as an androgen receptor agonist, which is a type of small molecule that binds to the androgen receptor. It is used to treat conditions such as hypogonadism, testosterone deficiency, and estrogen deficiency, as indicated by ClinicalTrials.gov.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}