{"id":"tertatolol","rwe":[{"pmid":"36999379","year":"2023","title":"The small molecule ACM-001 improves cardiac function in a rat model of severe cancer cachexia.","finding":"","journal":"European journal of heart failure","studyType":"Clinical Study"},{"pmid":"32036299","year":"2020","title":"Preparation and application of teicoplanin functionalized polymeric monolith for enantioseparation of chiral drugs.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"25476312","year":"2015","title":"Immobilized β-cyclodextrin-based silica vs polymer monoliths for chiral nano liquid chromatographic separation of racemates.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"21384438","year":"2011","title":"Stereoselective HPLC analysis of tertatolol in rat plasma using macrocyclic antibiotic chiral stationary phase.","finding":"","journal":"Chirality","studyType":"Clinical Study"},{"pmid":"18559985","year":"2008","title":"Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men.","finding":"","journal":"American journal of physiology. Endocrinology and metabolism","studyType":"Clinical Study"}],"tags":[{"label":"tertatolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-3 adrenergic receptor","category":"target"},{"label":"ADRB3","category":"gene"},{"label":"HTR1A","category":"gene"},{"label":"C07AA16","category":"atc"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dl-tertatolol","offLabel":[],"synonyms":["tertatolol","dl-Tertatolol"],"timeline":[],"approvals":[],"brandName":"Dl-Tertatolol","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 1A, Beta-3 adrenergic receptor, 5-hydroxytryptamine receptor 1A","targets":[{"gene":"ADRB3","source":"DrugCentral","target":"Beta-3 adrenergic receptor","protein":"Beta-3 adrenergic receptor"},{"gene":"HTR1A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1A","protein":"5-hydroxytryptamine receptor 1A"}],"modality":"Small Molecule","drugClass":"tertatolol","explanation":"Think of it like a key fitting into a lock. Tertatolol is the key that fits into the beta-3 adrenergic receptor, a type of lock on cells. When the key fits into the lock, it triggers a response that helps regulate things like heart rate, blood pressure, and metabolism.","oneSentence":"Tertatolol works by binding to and activating the beta-3 adrenergic receptor, which is involved in regulating various physiological processes.","technicalDetail":"Tertatolol acts as a beta-3 adrenergic receptor agonist, binding to the receptor and activating its G-protein coupled signaling pathway, which ultimately leads to the activation of downstream effectors involved in regulating various physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2605","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TERTATOLOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TERTATOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:51:07.654621","biosimilars":[],"competitors":[{"drugName":"oxprenolol","drugSlug":"oxprenolol","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"pindolol","drugSlug":"pindolol","fdaApproval":"1982-09-03","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"propranolol","drugSlug":"propranolol","fdaApproval":"1967-11-13","patentExpiry":"Oct 16, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"timolol","drugSlug":"timolol","fdaApproval":"1978-08-17","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sotalol","drugSlug":"sotalol","fdaApproval":"1992-10-30","patentExpiry":"Nov 19, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"nadolol","drugSlug":"nadolol","fdaApproval":"1979-12-10","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"carteolol","drugSlug":"carteolol","fdaApproval":"1988-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"penbutolol","drugSlug":"penbutolol","fdaApproval":"1987-12-30","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"tertatolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"oxprenolol","brandName":"oxprenolol","genericName":"oxprenolol","approvalYear":"","relationship":"same-class"},{"drugId":"pindolol","brandName":"pindolol","genericName":"pindolol","approvalYear":"1982","relationship":"same-class"},{"drugId":"propranolol","brandName":"propranolol","genericName":"propranolol","approvalYear":"1967","relationship":"same-class"},{"drugId":"timolol","brandName":"timolol","genericName":"timolol","approvalYear":"1978","relationship":"same-class"},{"drugId":"sotalol","brandName":"sotalol","genericName":"sotalol","approvalYear":"1992","relationship":"same-class"},{"drugId":"nadolol","brandName":"nadolol","genericName":"nadolol","approvalYear":"1979","relationship":"same-class"},{"drugId":"carteolol","brandName":"carteolol","genericName":"carteolol","approvalYear":"1988","relationship":"same-class"},{"drugId":"penbutolol","brandName":"penbutolol","genericName":"penbutolol","approvalYear":"1987","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07345104","phase":"NA","title":"Accuracy of Digital Mandibular Repositioning in Occlusal Reconstruction for Patients With Disc Displacement","status":"COMPLETED","sponsor":"Fujian Medical University","startDate":"2025-06-20","conditions":["Temporomandibular Joint Disc Displacement"],"enrollment":48,"completionDate":"2025-12-20"},{"nctId":"NCT07090772","phase":"NA","title":"The Effectiveness of Different Therapeutic Jaw Position Determining Methods in Repositioning Splint Therapy for Temporomandibular Joint Disk Displacement Without Reduction：A Randomized Controlled Clinical Trial","status":"ENROLLING_BY_INVITATION","sponsor":"Fujian Medical University","startDate":"2025-07-20","conditions":["Temporomandibular Disorder (TMD)"],"enrollment":45,"completionDate":"2026-08-20"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005762","UNII":"9ZO341YQXP","CHEBI":"CHEBI:135244","INN_ID":"5211","RXNORM":"37840","UMLSCUI":"C0076166","ChEMBL_ID":"CHEMBL434200","KEGG_DRUG":"D07182","DRUGBANK_ID":"DB13775","PUBCHEM_CID":"36920","SNOMEDCT_US":"716124003","IUPHAR_LIGAND_ID":"571","MESH_SUPPLEMENTAL_RECORD_UI":"C005632"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"60%"},"publicationCount":0,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"C07AA16","allCodes":["C07AA16"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 May","pmid":"36999379","title":"The small molecule ACM-001 improves cardiac function in a rat model of severe cancer cachexia.","journal":"European journal of heart failure"},{"date":"2020 Apr 15","pmid":"32036299","title":"Preparation and application of teicoplanin functionalized polymeric monolith for enantioseparation of chiral drugs.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2015 Jan","pmid":"25476312","title":"Immobilized β-cyclodextrin-based silica vs polymer monoliths for chiral nano liquid chromatographic separation of racemates.","journal":"Talanta"},{"date":"2011 Apr","pmid":"21384438","title":"Stereoselective HPLC analysis of tertatolol in rat plasma using macrocyclic antibiotic chiral stationary phase.","journal":"Chirality"},{"date":"2008 Aug","pmid":"18559985","title":"Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men.","journal":"American journal of physiology. Endocrinology and metabolism"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dl-Tertatolol is a small molecule with synonyms including ARTEX, ARTEXAL, PRENALEX, SE-2395, TERTATOLOL, and TERTATOLOL. Its modality is classified as a small molecule.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}