{"id":"terlipressin-administration","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Ischemic complications (rare)"}]},"_chembl":{"chemblId":"CHEMBL2135460","moleculeType":"Protein","molecularWeight":"1227.40"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Terlipressin binds to vasopressin V1 receptors on splanchnic and systemic blood vessels, causing vasoconstriction that decreases portal venous inflow and reduces portal hypertension. This mechanism makes it effective in acute variceal bleeding and hepatorenal syndrome by improving renal perfusion and reducing bleeding from esophageal varices in cirrhotic patients.","oneSentence":"Terlipressin is a vasopressin analog that selectively activates V1 receptors on vascular smooth muscle to cause vasoconstriction and reduce portal pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:38:08.680Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute variceal bleeding in patients with portal hypertension"},{"name":"Hepatorenal syndrome (HRS) in cirrhotic patients"}]},"trialDetails":[{"nctId":"NCT07460908","phase":"NA","title":"Comparison of Terlipressin Versus Octreotide in Patients With Hepatorenal Syndrome","status":"COMPLETED","sponsor":"Lahore General Hospital","startDate":"2025-05-01","conditions":"Hepatorenal Syndrome","enrollment":60},{"nctId":"NCT02970175","phase":"PHASE3","title":"Interest of in Situ Terlipressin Administration Before the Realisation of Bronchial Biopsy","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2017-06-30","conditions":"Bronchial Endoscopy","enrollment":130},{"nctId":"NCT06161766","phase":"","title":"Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal Disease","status":"COMPLETED","sponsor":"University Hospital Freiburg","startDate":"2024-03-03","conditions":"Liver Cirrhosis, Hepato-Renal Syndrome, Chronic Kidney Diseases","enrollment":490},{"nctId":"NCT07252401","phase":"NA","title":"Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Gastrointestinal Bleeding and Acute Kidney Injury","status":"NOT_YET_RECRUITING","sponsor":"General Hospital of Shenyang Military Region","startDate":"2025-12-25","conditions":"Liver Cirrhosis","enrollment":64},{"nctId":"NCT07131306","phase":"PHASE2","title":"National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2027-01","conditions":"Acute-On-Chronic Liver Failure","enrollment":100},{"nctId":"NCT07075315","phase":"PHASE3","title":"National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2028-01","conditions":"Acute-On-Chronic Liver Failure","enrollment":100},{"nctId":"NCT06855758","phase":"NA","title":"Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation","status":"RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2025-03-06","conditions":"Kidney Transplant, Delayed Graft Function, Intraoperative Hypotension","enrollment":150},{"nctId":"NCT06256432","phase":"PHASE2","title":"Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome","status":"RECRUITING","sponsor":"Noorik Biopharmaceuticals AG","startDate":"2024-04-17","conditions":"Hepatorenal Syndrome, Liver Cirrhosis, Acute Kidney Injury","enrollment":54},{"nctId":"NCT05346393","phase":"NA","title":"HRS-AKI Treatment With TIPS in Patients With Cirrhosis","status":"RECRUITING","sponsor":"Jena University Hospital","startDate":"2022-11-29","conditions":"Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury","enrollment":124},{"nctId":"NCT04112199","phase":"PHASE2","title":"A Study for Evaluation of BIV201 to Reduce Ascites and Complications in Patients With Cirrhosis and Refractory Ascites","status":"TERMINATED","sponsor":"BioVie Inc.","startDate":"2021-06-17","conditions":"Ascites, Decompensated Cirrhosis","enrollment":15},{"nctId":"NCT04961528","phase":"PHASE3","title":"ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial.","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-03-27","conditions":"Hemoptysis","enrollment":315},{"nctId":"NCT03130127","phase":"NA","title":"Continuous Versus Bolus Infusion of Terlipressin for Portal Hypertension Related Bleeding in Liver Cirrhosis","status":"UNKNOWN","sponsor":"General Hospital of Shenyang Military Region","startDate":"2024-07-01","conditions":"Liver Cirrhosis, Portal Hypertension, Variceal Hemorrhage","enrollment":40},{"nctId":"NCT06122792","phase":"NA","title":"Preemptive TIPS for Gastric Variceal Bleeding in Patients With Cirrhosis","status":"NOT_YET_RECRUITING","sponsor":"West China Hospital","startDate":"2024-01","conditions":"Portal Hypertension, Gastric Varices Bleeding, Portosystemic Shunt","enrollment":144},{"nctId":"NCT06122753","phase":"NA","title":"Preemptive TIPS for Variceal Bleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis","status":"NOT_YET_RECRUITING","sponsor":"West China Hospital","startDate":"2024-01","conditions":"Portal Hypertension, Portal Vein Thrombosis, Esophageal Varix Bleeding","enrollment":120},{"nctId":"NCT05875948","phase":"PHASE2","title":"Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome","status":"UNKNOWN","sponsor":"River 2 Renal Corp.","startDate":"2023-06-30","conditions":"Hepatorenal Syndrome, Acute Kidney Injury","enrollment":95},{"nctId":"NCT06027970","phase":"PHASE3","title":"Efficacy of Continuous Terlipressin Therapy After Endoscopic Variceal Ligation","status":"UNKNOWN","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2023-09","conditions":"Variceal Hemorrhage","enrollment":165},{"nctId":"NCT05699824","phase":"NA","title":"To Study the Hemodynamic Response of Early Addition of Carvedilol to Terlipressin in Acute Variceal Bleed in Child's B and C Cirrhosis","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2023-07-01","conditions":"Liver Cirrhosis","enrollment":100},{"nctId":"NCT03822091","phase":"PHASE3","title":"Terlipressin Infusion Alone Vs Terlipressin With Noradrenaline Infusion In The Treatment of Hepatorenal Syndrome Type 1","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2019-01-28","conditions":"Type 1 HEPATO RENAL SYNDROME(HRS)","enrollment":60},{"nctId":"NCT05207280","phase":"PHASE3","title":"Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic Shock","status":"UNKNOWN","sponsor":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","startDate":"2022-10-11","conditions":"Septic Shock","enrollment":152},{"nctId":"NCT04416282","phase":"NA","title":"Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.","status":"COMPLETED","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2020-06-22","conditions":"Acute-On-Chronic Liver Failure, Hepatorenal Syndrome, Acute Kidney Injury","enrollment":70},{"nctId":"NCT05331768","phase":"NA","title":"Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy","status":"COMPLETED","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2021-01-01","conditions":"Esophageal and Gastric Varices","enrollment":109},{"nctId":"NCT04819568","phase":"NA","title":"Comparison of Bolus Versus Continuous Infusion of Terlipressin Cirrhotic Patients With Septic Shock.","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2021-06-25","conditions":"Liver Cirrhosis","enrollment":310},{"nctId":"NCT05080543","phase":"PHASE1","title":"Microcirculation Recruitment Using Albumin 20% and Terlipressin in Septic Patients","status":"UNKNOWN","sponsor":"Amany Mousa Salama Muhammed","startDate":"2021-10","conditions":"Septic Shock","enrollment":36},{"nctId":"NCT03107091","phase":"PHASE2","title":"Continuous Infusion Terlipressin for Patients With Cirrhosis and Refractory Ascites","status":"COMPLETED","sponsor":"BioVie Inc.","startDate":"2017-07-15","conditions":"Cirrhosis, Ascites Hepatic","enrollment":6},{"nctId":"NCT04948372","phase":"NA","title":"Effects of Terlipressin on Renal Perfusion in Patients With Septic Shock","status":"COMPLETED","sponsor":"Southeast University, China","startDate":"2019-09-01","conditions":"Septic Shock","enrollment":22},{"nctId":"NCT04221672","phase":"PHASE3","title":"The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2019-11-07","conditions":"Terlipressin Adverse Reaction, Ascites Hepatic, Liver Failure","enrollment":86},{"nctId":"NCT04110418","phase":"PHASE2","title":"Methylene Blue Versus Vasopressin Analogue for Treatment of Septic Shock in Preterm Neonate","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2019-02-19","conditions":"Neonatal Sepsis, Refractory Shock","enrollment":36},{"nctId":"NCT04013113","phase":"NA","title":"Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With Acute on Chronic Liver Failure","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2019-07-09","conditions":"Acute-On-Chronic Liver Failure","enrollment":250},{"nctId":"NCT02726620","phase":"NA","title":"Decision Support for Intraoperative Low Blood Pressure","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2017-01-05","conditions":"Hypotension","enrollment":22435},{"nctId":"NCT01370161","phase":"NA","title":"Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis","status":"COMPLETED","sponsor":"Air Force Military Medical University, China","startDate":"2011-07","conditions":"Decompensated Cirrhosis, Bleeding Varices","enrollment":132},{"nctId":"NCT03336814","phase":"PHASE4","title":"Evaluation of Early Association of Terlipressin and Norepinephrine During Septic Shock; the TerliNor Study","status":"UNKNOWN","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2018-07-27","conditions":"Septic Shock","enrollment":40},{"nctId":"NCT01921985","phase":"PHASE2","title":"Terlipressin Administration in Patients Undergoing Major Liver Resection","status":"TERMINATED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2013-11","conditions":"Liver Resection, Liver Failure","enrollment":150},{"nctId":"NCT03477461","phase":"","title":"Effects of Terlipressin on Management of Potential Organ Donors","status":"COMPLETED","sponsor":"First Affiliated Hospital, Sun Yat-Sen University","startDate":"2015-01-01","conditions":"Organ Donors","enrollment":18},{"nctId":"NCT00966355","phase":"PHASE4","title":"Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding","status":"COMPLETED","sponsor":"Korea University","startDate":"2006-09","conditions":"Variceal Bleeding, Cirrhosis","enrollment":1034},{"nctId":"NCT02364297","phase":"NA","title":"TIPS in Fundal Variceal Bleeding (the TFB Study)","status":"UNKNOWN","sponsor":"Institut d'Investigacions Biomèdiques August Pi i Sunyer","startDate":"2015-09","conditions":"Portal Hypertension, Bleeding Gastric Varices","enrollment":60},{"nctId":"NCT02368249","phase":"PHASE2","title":"Does Terlipressin Improve Renal Outcome After Liver Surgery","status":"WITHDRAWN","sponsor":"University of Zurich","startDate":"2020-01","conditions":"Kidney Failure","enrollment":""},{"nctId":"NCT01278199","phase":"NA","title":"Bronchial Artery Embolization and Medical Measures in Non Severe Acute Hemoptysis of Mild-moderate Abundance","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2011-11","conditions":"Hemoptysis, Acute Disease","enrollment":73},{"nctId":"NCT01530711","phase":"PHASE4","title":"Treatment of Hepatorenal Syndrome With Terlipressin Infusion Adjusted to Hemodynamic Response","status":"UNKNOWN","sponsor":"Pere Gines","startDate":"2012-04","conditions":"Cirrhosis, Hepatorenal Syndrome Type I","enrollment":40},{"nctId":"NCT02757703","phase":"PHASE4","title":"Vasoactive Drugs in Real World Practice","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2010-05","conditions":"Vasoconstrictor Choice on Acute Variceal Bleeding","enrollment":150},{"nctId":"NCT00628160","phase":"PHASE2, PHASE3","title":"Terlipressin in Septic Shock in Cirrhosis","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2006-10","conditions":"Liver Cirrhosis, Septic Shock","enrollment":72},{"nctId":"NCT00742339","phase":"PHASE2, PHASE3","title":"Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal Syndrome","status":"TERMINATED","sponsor":"University of Padova","startDate":"2005-05","conditions":"Cirrhosis, Hepatorenal Syndrome","enrollment":49},{"nctId":"NCT01932151","phase":"NA","title":"Treatment of Type-1 Hepatorenal Syndrome Associated With Sepsis","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2012-12","conditions":"Hepatorenal Syndrome","enrollment":18},{"nctId":"NCT01079715","phase":"PHASE2, PHASE3","title":"Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity","status":"COMPLETED","sponsor":"Meyer Children's Hospital IRCCS","startDate":"2010-01","conditions":"Retinopathy of Prematurity","enrollment":52},{"nctId":"NCT01335516","phase":"","title":"Follow-up of Glypressin (Terlipressin) Clinical Efficacy in the Treatment of Bleeding Oesophageal Varices","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2010-11","conditions":"Gastrointestinal Bleeding, Oesophageal Varices","enrollment":20},{"nctId":"NCT01637454","phase":"PHASE3","title":"TYPE 2 HEPATORENAL SYNDROME","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2009-01","conditions":"Safety and Efficacy of Terlipressin and Noradrenaline and Predictive Factors of Response in Type 2 HRS","enrollment":46},{"nctId":"NCT00995839","phase":"PHASE2, PHASE3","title":"Terlipressin in Septic Shock: Effects on Microcirculation","status":"COMPLETED","sponsor":"University of Roma La Sapienza","startDate":"2008-11","conditions":"Septic Shock, Sepsis","enrollment":60},{"nctId":"NCT00793559","phase":"PHASE2","title":"Terlipressin Administration in Septic Shock Refractory to Catecholamines","status":"UNKNOWN","sponsor":"Assaf-Harofeh Medical Center","startDate":"2008-11","conditions":"Septic Shock","enrollment":30},{"nctId":"NCT00287664","phase":"PHASE4","title":"Treatment of Hepatorenal Syndrome With Terlipressin Plus Albumin vs Albumin","status":"SUSPENDED","sponsor":"Hospital Clinic of Barcelona","startDate":"2002-02","conditions":"Cirrhosis, Hepatorenal Syndrome","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":57,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Terlipressin administration","genericName":"Terlipressin administration","companyName":"University Hospital, Rouen","companyId":"university-hospital-rouen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Terlipressin is a vasopressin analog that selectively activates V1 receptors on vascular smooth muscle to cause vasoconstriction and reduce portal pressure. Used for Acute variceal bleeding in patients with portal hypertension, Hepatorenal syndrome (HRS) in cirrhotic patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}