{"id":"terbutaline-infusion","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Tremor"},{"rate":"5-10","effect":"Tachycardia"},{"rate":"5-10","effect":"Headache"},{"rate":"3-8","effect":"Palpitations"},{"rate":"5-10","effect":"Nervousness/anxiety"},{"rate":"2-5","effect":"Muscle cramps"}]},"_chembl":{"chemblId":"CHEMBL1315867","moleculeType":"Small molecule","molecularWeight":"548.66"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Terbutaline binds to and activates beta-2 adrenergic receptors on bronchial smooth muscle cells, triggering a cascade that increases intracellular cAMP levels. This leads to smooth muscle relaxation and bronchodilation, rapidly relieving airway obstruction. When given as an infusion, it provides sustained systemic delivery for acute bronchospasm management.","oneSentence":"Terbutaline is a beta-2 adrenergic agonist that stimulates beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:11:39.895Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute bronchospasm and reversible airway obstruction in asthma and COPD"},{"name":"Premature labor (tocolytic use, though less common in modern practice)"}]},"trialDetails":[{"nctId":"NCT05193968","phase":"NA","title":"Hot Flashes and Neurovascular Function in Women","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2022-02-24","conditions":"Hot Flashes, Menopause, Vasomotor System; Labile","enrollment":120},{"nctId":"NCT06626620","phase":"PHASE3","title":"Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in the Management of Acute Exacerbation of Asthma","status":"COMPLETED","sponsor":"Muhammad Aamir Latif","startDate":"2024-01-01","conditions":"Acute Exacerbation of Asthma","enrollment":120},{"nctId":"NCT00802230","phase":"PHASE4","title":"Pharmacodynamic Study of Carvedilol Versus Metoprolol in Heart Failure","status":"COMPLETED","sponsor":"University of Utah","startDate":"2002-09","conditions":"Heart Failure","enrollment":25},{"nctId":"NCT04468568","phase":"","title":"In Utero Repair of Myelomeningocele: Atosiban Versus Terbutaline","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2017-10-01","conditions":"Myelomeningocele, Terbutaline Adverse Reaction, Pregnancy; Malformation Central Nervous System","enrollment":25},{"nctId":"NCT01081002","phase":"PHASE4","title":"Propofol Sedation During Upper Endoscopy With and Without Topical Pharyngeal Anesthesia","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2009-08","conditions":"Conscious Sedation","enrollment":294},{"nctId":"NCT00974051","phase":"NA","title":"Use of Terbutaline or a Reduction in Basal Insulin in the Prevention of Nocturnal Hypoglycemia","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2008-03","conditions":"Type 1 Diabetes","enrollment":16},{"nctId":"NCT00750568","phase":"","title":"Intravenous Terbutaline in Severe Status Asthmaticus","status":"UNKNOWN","sponsor":"Wayne State University","startDate":"2007-10","conditions":"Status Asthmaticus","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":67,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Terbutaline Infusion","genericName":"Terbutaline Infusion","companyName":"Muhammad Aamir Latif","companyId":"muhammad-aamir-latif","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Terbutaline is a beta-2 adrenergic agonist that stimulates beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow. Used for Acute bronchospasm and reversible airway obstruction in asthma and COPD, Premature labor (tocolytic use, though less common in modern practice).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}