{"id":"terbinafine-hydrogen-chloride","safety":{"commonSideEffects":[{"rate":"2-3","effect":"Headache"},{"rate":"2-3","effect":"Diarrhea"},{"rate":"1-2","effect":"Rash"},{"rate":"1-2","effect":"Dyspepsia"},{"rate":"0.5-1","effect":"Taste disturbance"},{"rate":"0.1-0.3","effect":"Hepatotoxicity"},{"rate":"<0.1","effect":"Stevens-Johnson syndrome"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Terbinafine is a fungicidal agent that selectively inhibits the enzyme squalene epoxidase in the fungal sterol synthesis pathway. By blocking ergosterol production, an essential component of fungal cell membranes, the drug causes membrane instability and fungal cell death. It is particularly effective against dermatophytes and has broad antifungal activity.","oneSentence":"Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:38:10.238Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"},{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea cruris (jock itch)"}]},"trialDetails":[{"nctId":"NCT00443898","phase":"PHASE3","title":"Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2006-12","conditions":"Onychomycosis","enrollment":518},{"nctId":"NCT00459537","phase":"PHASE3","title":"Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis","status":"COMPLETED","sponsor":"Novartis","startDate":"2007-03","conditions":"Onychomycosis","enrollment":1029},{"nctId":"NCT00443820","phase":"PHASE3","title":"Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2006-12","conditions":"Onychomycosis","enrollment":526},{"nctId":"NCT00691184","phase":"PHASE1","title":"Safety and Pharmacokinetics of Terbinafine Hydrogen Chloride (HCl) Nail Lacquer in Patients With Onychomycosis","status":"COMPLETED","sponsor":"NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences, Inc.)","startDate":"2005-02","conditions":"Onychomycosis/Onycholysis and Tinea Pedis","enrollment":56}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lamisil"],"phase":"phase_3","status":"active","brandName":"terbinafine hydrogen chloride","genericName":"terbinafine hydrogen chloride","companyName":"Novartis","companyId":"novartis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death. Used for Onychomycosis (fungal nail infection), Tinea pedis (athlete's foot), Tinea corporis (ringworm).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}