{"id":"tepoxalin","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin G/H synthase 2","category":"target"},{"label":"PTGS2","category":"gene"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Immunologic Factors","category":"pharmacology"},{"label":"Immunosuppressive Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["tepoxalin"],"offLabel":[],"synonyms":["tepoxalin"],"timeline":[],"aiSummary":"TEPOXALIN is a small molecule modality targeting Prostaglandin G/H synthase 2, a key enzyme involved in inflammation. However, due to the lack of available information, its exact mechanism of action, commercial status, and approved indications are unknown. As a result, it is difficult to provide a comprehensive summary of this compound. Further research is needed to determine its potential as a therapeutic agent. Unfortunately, without more information, it is challenging to assess its safety profile and potential side effects.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"ecosystem":[],"mechanism":{"target":"Prostaglandin G/H synthase 2, Arachidonate 5-lipoxygenase, Prostaglandin G/H synthase 1","novelty":"First-in-class","targets":[{"gene":"PTGS2","source":"DrugCentral","target":"Prostaglandin G/H synthase 2","protein":"Prostaglandin G/H synthase 2"}],"modality":"Small Molecule","explanation":"Think of it like a fire: Prostaglandin G/H synthase 2 is like the fuel that keeps the fire burning. TEPOXALIN is like a fire extinguisher that helps put out the fire by reducing the amount of fuel available. By doing so, it can help reduce inflammation and alleviate symptoms associated with various conditions.","oneSentence":"TEPOXALIN works by inhibiting the enzyme Prostaglandin G/H synthase 2, which plays a crucial role in the production of inflammatory mediators.","technicalDetail":"TEPOXALIN exerts its effects by competitively inhibiting the cyclooxygenase (COX) activity of Prostaglandin G/H synthase 2, thereby reducing the production of prostaglandins and thromboxanes, which are key mediators of inflammation and pain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5624","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TEPOXALIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:50:12.504862","biosimilars":[],"competitors":[{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-target"},{"drugName":"acetylsalicylic acid","drugSlug":"acetylsalicylic-acid","fdaApproval":"1950-04-12","relationship":"same-target"},{"drugName":"balsalazide","drugSlug":"balsalazide","fdaApproval":"2000-07-18","patentExpiry":"Jun 23, 2031","patentStatus":"Patent 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