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Once incorporated, it terminates the DNA chain, preventing HIV replication.","oneSentence":"Tenofovir inhibits HIV reverse transcriptase by competing with natural substrates and causing DNA chain termination."},"_scrapedAt":"2026-03-28T01:38:10.419Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779122772,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"lamivudine","brand":"Epivir","company":"ViiV Healthcare","rationale":"Nucleoside reverse transcriptase inhibitor for HIV treatment"},{"name":"emtricitabine","brand":"Emtriva","company":"Gilead Sciences","rationale":"Nucleoside reverse transcriptase inhibitor, similar mechanism"},{"name":"abacavir","brand":"Ziagen","company":"ViiV Healthcare","rationale":"Nucleoside reverse transcriptase inhibitor for HIV"}],"description":"Tenofovir monotherapy refers to the use of tenofovir as a single antiretroviral agent. Tenofovir is a nucleotide reverse transcriptase inhibitor typically used in combination therapy for HIV treatment and prevention. Monotherapy approaches are being investigated by Uijeongbu St. Mary Hospital in phase 3 studies.","indications":{"approved":[{"status":"investigational","condition":"HIV infection","patientPopulation":"investigational as monotherapy"}]},"trialDetails":[{"nctId":"NCT07095855","phase":"PHASE3","title":"A Phase III Study to Evaluate the Efficacy and Safety of ZM-H1505R in Patients With CHB","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Zhimeng Biopharma, Inc.","startDate":"2025-08","conditions":"Chronic Hepatitis B","enrollment":1300},{"nctId":"NCT07079150","phase":"","title":"Real-world Study Evaluating the Long-term Outcomes of Pegylated Interferon α-2b Treatment in the Families With Clusters of HBV Infection and Unfavorable Prognosis - A Prospective, Controlled, Multicenter, Cohort Study","status":"RECRUITING","sponsor":"First Affiliated Hospital Xi'an Jiaotong University","startDate":"2025-01-01","conditions":"Hepatitis B, Chronic (CHB), Hepatitis B, Hepatitis B Virus (HBV)","enrollment":1500},{"nctId":"NCT05182463","phase":"PHASE4","title":"Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients","status":"RECRUITING","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2022-01-08","conditions":"Hepatitis B, Chronic","enrollment":5000},{"nctId":"NCT03804372","phase":"PHASE2","title":"The Incidence of Hepatitis B in Diffuse Large B-Cell Lymphoma/Chronic Lymphoid Leukemia HBsAg-positive Treated With Rituximab, Chemotherapy and Tenofovir Alafenamide","status":"TERMINATED","sponsor":"Gruppo Italiano Malattie EMatologiche dell'Adulto","startDate":"2020-07-07","conditions":"Large-B-cell Diffuse Lymphoma, Chronic Lymphoid Leukemia","enrollment":5},{"nctId":"NCT06150014","phase":"PHASE1, PHASE2","title":"A Clinical Study of TQA3605 Tablets Monotherapy or in Combination With Nucleoside (Acid) Analogues in Treatment Naive and Treated Patients With Chronic Hepatitis B","status":"ACTIVE_NOT_RECRUITING","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2023-12-07","conditions":"Chronic Hepatitis b","enrollment":88},{"nctId":"NCT06323681","phase":"NA","title":"Pegylated Interferon α in Previously Interferon-treated CHB（Leading Study）","status":"RECRUITING","sponsor":"Qing XIe","startDate":"2024-02-04","conditions":"Chronic Hepatitis b","enrollment":2016},{"nctId":"NCT04640129","phase":"PHASE4","title":"HBsAg Seroclearance in Adults With HBV Related Liver Fibrosis After Receiving Combined Therapy of Peg-IFN and Tenofovir.","status":"UNKNOWN","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2021-01-01","conditions":"Liver Fibrosis","enrollment":336},{"nctId":"NCT05937178","phase":"","title":"Real-world Study Optimizing Nucleotide-analogues","status":"RECRUITING","sponsor":"Huashan Hospital","startDate":"2023-01-31","conditions":"Hepatitis B, Chronic","enrollment":20000},{"nctId":"NCT05808335","phase":"PHASE2","title":"A Study to Assess the Efficacy and 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to Monotherapy With Tenofovir in ACLF-HBV","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2020-06-22","conditions":"Acute-On-Chronic Liver Failure, Hepatitis B","enrollment":70},{"nctId":"NCT05203055","phase":"PHASE1, PHASE2","title":"Peginterferon Alpha-2b Therapy in Chronic Hepatitis Patients With Normal ALT Level and Low Viremia","status":"UNKNOWN","sponsor":"Fuzhou General Hospital","startDate":"2021-12-10","conditions":"Chronic Hepatitis B Patients With a Normal ALT Level and Low Viremia","enrollment":300},{"nctId":"NCT05063071","phase":"PHASE4","title":"Tenofovir Alafenamide for HBV Prophylaxis in Post Orthotopic Liver Transplant","status":"UNKNOWN","sponsor":"Fudan University","startDate":"2021-07-29","conditions":"HBV, POST LIVER TRANSPLANT","enrollment":150},{"nctId":"NCT00214890","phase":"PHASE2","title":"Viral Dynamics and Pharmacokinetics of Abacavir and Tenofovir","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2004-12-07","conditions":"HIV Infections","enrollment":21},{"nctId":"NCT03241641","phase":"PHASE4","title":"Switching From TDF to TAF vs. Maintaining TDF in Chronic Hepatitis B With Resistance to Adefovir or Entecavir.","status":"COMPLETED","sponsor":"Young-Suk Lim","startDate":"2017-10-26","conditions":"Chronic Hepatitis b","enrollment":174},{"nctId":"NCT04650828","phase":"","title":"TDF Combined With LDT for the Treatment of HBeAg-positive Hepatitis B Patients With Poor Response to TDF for 12 Months","status":"UNKNOWN","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2020-12-01","conditions":"Chronic Hepatitis B","enrollment":200},{"nctId":"NCT03472326","phase":"PHASE2","title":"Study to Evaluate the Efficacy of GS-9131 Functional Monotherapy in Human Immunodeficiency Virus (HIV)-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen With Nucleos(t)Ide Reverse Transcriptase Inhibitor Resistant Virus","status":"TERMINATED","sponsor":"Gilead Sciences","startDate":"2018-04-03","conditions":"HIV-1-infection","enrollment":21},{"nctId":"NCT02751996","phase":"PHASE2","title":"A Study Evaluating the Safety, Pharmacokinetics, and Antiviral Efficacy of SB 9200 in Subjects Infected With Chronic HBV","status":"COMPLETED","sponsor":"F-star Therapeutics, Inc.","startDate":"2016-05","conditions":"Hepatitis B, Hepatitis, Viral","enrollment":80},{"nctId":"NCT04157699","phase":"PHASE2","title":"An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Tenofovir in Naive Patients With Chronic Hepatitis b","status":"UNKNOWN","sponsor":"Qilu Pharmaceutical Co., Ltd.","startDate":"2019-07-26","conditions":"Chronic Hepatitis b","enrollment":100},{"nctId":"NCT04157257","phase":"PHASE2","title":"An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Entecavir or Tenofovir in Patients With Chronic Hepatitis b Who Have Received Nucleoside (Acid) 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It has been studied as a treatment for Hepatitis B and Chronic Hepatitis B in clinical trials, including a Phase 3b study comparing its efficacy to emtricitabine/tenofovir.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}