{"id":"tenitramine","rwe":[],"tags":[{"label":"Vasodilators Organic Nitrates","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01DA38","category":"atc"},{"label":"Active","category":"status"},{"label":"Angina pectoris","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["tenitramine"],"offLabel":[],"synonyms":["tenitramine"],"timeline":[],"approvals":[],"ecosystem":[{"indication":"Angina pectoris","otherDrugs":[{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"},{"name":"atenolol","slug":"atenolol","company":"Alvogen Ipco Sarl"},{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"bepridil","slug":"bepridil","company":""}],"globalPrevalence":112000000}],"mechanism":{"modality":"Small Molecule","drugClass":"Vasodilators Organic Nitrates","explanation":"When you have angina, your heart muscle doesn't get enough oxygen-rich blood. Tenitramine helps by releasing nitric oxide, which is a natural chemical that relaxes the muscles in the walls of blood vessels. This relaxation allows more blood to flow to the heart, reducing the frequency and severity of angina attacks.","oneSentence":"Tenitramine works by releasing nitric oxide, which relaxes blood vessels and improves blood flow to the heart.","technicalDetail":"Tenitramine acts as a prodrug, releasing nitric oxide through enzymatic degradation, which then activates guanylyl cyclase and increases cyclic guanosine monophosphate (cGMP) levels, leading to smooth muscle relaxation and vasodilation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2591","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tenitramine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:49:58.397056","biosimilars":[],"competitors":[{"drugName":"glyceryl trinitrate","drugSlug":"glyceryl-trinitrate","fdaApproval":"1981-05-28","relationship":"same-class"},{"drugName":"isosorbide dinitrate","drugSlug":"isosorbide-dinitrate","fdaApproval":"1968-01-16","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"isosorbide mononitrate","drugSlug":"isosorbide-mononitrate","fdaApproval":"1991-12-30","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"tenitramine","indications":{"approved":[{"name":"Angina pectoris","source":"DrugCentral","snomedId":194828000,"regulator":"FDA","usPrevalence":null,"globalPrevalence":112000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"glyceryl-trinitrate","brandName":"glyceryl trinitrate","genericName":"glyceryl trinitrate","approvalYear":"1981","relationship":"same-class"},{"drugId":"isosorbide-dinitrate","brandName":"isosorbide dinitrate","genericName":"isosorbide dinitrate","approvalYear":"1968","relationship":"same-class"},{"drugId":"isosorbide-mononitrate","brandName":"isosorbide mononitrate","genericName":"isosorbide mononitrate","approvalYear":"1991","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"CKB16BAQ3S","UMLSCUI":"C0603972","ChEMBL_ID":"CHEMBL3707257","DRUGBANK_ID":"DB13637","PUBCHEM_CID":"168009","MESH_SUPPLEMENTAL_RECORD_UI":"C009395"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01DA38","allCodes":["C01DA38"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"tenitramine","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Tenitramine is a small molecule vasodilator in the organic nitrates class. It works by releasing nitric oxide, which relaxes blood vessels and improves blood flow to the heart, reducing the frequency and severity of angina attacks. Tenitramine is approved to treat angina pectoris, but its commercial status and key safety considerations are unknown. As a vasodilator, it may cause hypotension and reflex tachycardia, and patients should be monitored for these effects. Further research is needed to fully understand its pharmacokinetics and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}