{"id":"temozolomide-tace","safety":{"commonSideEffects":[{"rate":"20-50%","effect":"Nausea"},{"rate":"10-30%","effect":"Vomiting"},{"rate":"10-30%","effect":"Fatigue"},{"rate":"5-20%","effect":"Hair loss"},{"rate":"5-20%","effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Temozolomide is a type of chemotherapy medication that belongs to the class of alkylating agents. It works by attaching an alkyl group to the DNA of cancer cells, which prevents them from replicating and eventually leads to cell death. TACE, on the other hand, is a procedure that allows for the direct delivery of chemotherapy to the tumor site, increasing the concentration of the medication and reducing the side effects.","oneSentence":"Temozolomide is an alkylating agent that works by interfering with DNA replication in cancer cells, while TACE is a minimally invasive procedure that involves the insertion of a catheter to deliver chemotherapy directly to the tumor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:38:06.160Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glioblastoma"}]},"trialDetails":[{"nctId":"NCT05647954","phase":"PHASE3","title":"A Study of HX008 Plus Transcatheter Arterial Chemoembolization (TACE) in the First-Line Treatment of Subjects With Stage IV (M1c) Melanoma That is Metastatic to the Liver","status":"UNKNOWN","sponsor":"Taizhou Hanzhong biomedical co. LTD","startDate":"2022-12-31","conditions":"Melanoma Neuroendocrine Tumors Neuroectodermal Tumors Neoplasms Germ Cell and Embryonal Neoplasms by Histologic Type Neoplasms Neoplasms","enrollment":350}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Temozolomide + TACE","genericName":"Temozolomide + TACE","companyName":"Taizhou Hanzhong biomedical co. LTD","companyId":"taizhou-hanzhong-biomedical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Temozolomide is a small molecule DNA inhibitor used in cancer treatment. It is being studied in combination with Transcatheter Arterial Chemoembolization (TACE) for the treatment of stage IV melanoma that has metastasized to the liver.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}