{"id":"temocillin-pk-pd-in-haemodialysis","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Phlebitis at injection site"},{"rate":null,"effect":"Elevated liver enzymes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Temocillin is a carboxypenicillin with a broad spectrum of activity against gram-negative and gram-positive bacteria. It works by inhibiting cross-linking of peptidoglycan in the bacterial cell wall, leading to cell wall instability and bacterial death. This study examines its pharmacokinetics and pharmacodynamics specifically in haemodialysis patients, where renal clearance is impaired.","oneSentence":"Temocillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:11:37.868Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections in patients with renal impairment undergoing haemodialysis"},{"name":"Gram-negative and gram-positive bacterial infections (general)"}]},"trialDetails":[{"nctId":"NCT02285075","phase":"PHASE4","title":"Temocillin Pharmacokinetic in Hemodialysis","status":"COMPLETED","sponsor":"AZ Sint-Jan AV","startDate":"2011-06","conditions":"Gram-Negative Bacterial Infections, Renal Failure Chronic Requiring Hemodialysis","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"temocillin PK/PD in haemodialysis","genericName":"temocillin PK/PD in haemodialysis","companyName":"AZ Sint-Jan AV","companyId":"az-sint-jan-av","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Temocillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Used for Bacterial infections in patients with renal impairment undergoing haemodialysis, Gram-negative and gram-positive bacterial infections (general).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}