{"id":"teicoplanin-antimicrobial-lock-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Local catheter site reactions"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Thrombophlebitis"}]},"_chembl":{"chemblId":"CHEMBL2367892","moleculeType":"Unknown","molecularWeight":"1767.46"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Teicoplanin works by preventing cross-linking of peptidoglycan strands in the bacterial cell wall, leading to cell wall instability and bacterial death. When used as an antimicrobial-lock solution, it is instilled into central venous catheters to prevent and treat catheter-related bloodstream infections by maintaining high local antibiotic concentrations at the catheter tip.","oneSentence":"Teicoplanin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala peptidoglycan precursors.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:11:29.926Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of central venous catheter-related bloodstream infections"},{"name":"Catheter lock therapy for hemodialysis and parenteral nutrition catheters"}]},"trialDetails":[{"nctId":"NCT01592032","phase":"PHASE4","title":"Concentration of Antimicrobials in Catheter-lock Solutions","status":"UNKNOWN","sponsor":"Clinica Universidad de Navarra, Universidad de Navarra","startDate":"2012-05","conditions":"Catheter-Related Infections, Bacteremia.","enrollment":125}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["teicoplanin: targocid 200 mg vial.","sodium heparin 1%, 5000 IU/5ml.","sodium chloride 0,9% 10 ml vial."],"phase":"marketed","status":"active","brandName":"Teicoplanin antimicrobial-lock solution","genericName":"Teicoplanin antimicrobial-lock solution","companyName":"Clinica Universidad de Navarra, Universidad de Navarra","companyId":"clinica-universidad-de-navarra-universidad-de-navarra","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Teicoplanin is used as an antimicrobial-lock solution to prevent or treat catheter-related infections and bacteremia. The exact mechanism of action of Teicoplanin is unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}