{"id":"tedisamil","rwe":[],"tags":[{"label":"tedisamil","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01BD06","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["KC-8857","tedisamil","tedisamil sesquifumarate"],"offLabel":[],"synonyms":["KC-8857","tedisamil","tedisamil sesquifumarate"],"timeline":[],"aiSummary":"Tedisamil is a small molecule that blocks voltage-gated potassium channels. It has been studied in clinical trials for the rapid conversion of atrial fibrillation or flutter to normal sinus rhythm in male subjects.","approvals":[],"ecosystem":[],"mechanism":{"target":"Potassium voltage-gated channel subfamily A member 7","modality":"Small Molecule","drugClass":"tedisamil","explanation":"Think of the heart as a muscle that needs to beat at a steady pace. Potassium channels help control how fast the heart beats. Tedisamil blocks these channels, which helps to slow down the heart rate and prevent it from beating too quickly or irregularly.","oneSentence":"Tedisamil works by blocking certain potassium channels in the heart, which helps to regulate the heartbeat and prevent abnormal rhythms.","technicalDetail":"Tedisamil acts as a selective blocker of the I_Ks potassium channel, which is involved in the repolarization phase of the cardiac action potential. By blocking this channel, tedisamil prolongs the action potential duration and refractory period, which helps to prevent abnormal heart rhythms."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4655","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TEDISAMIL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TEDISAMIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:49:04.063338","biosimilars":[],"competitors":[{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"bretylium","drugSlug":"bretylium","fdaApproval":"1986-03-06","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dofetilide","drugSlug":"dofetilide","fdaApproval":"1999-10-01","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ibutilide","drugSlug":"ibutilide","fdaApproval":"1995-12-28","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dronedarone","drugSlug":"dronedarone","fdaApproval":"2009-07-01","patentExpiry":"Jun 30, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"tedisamil","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-class"},{"drugId":"bretylium","brandName":"bretylium","genericName":"bretylium","approvalYear":"1986","relationship":"same-class"},{"drugId":"dofetilide","brandName":"dofetilide","genericName":"dofetilide","approvalYear":"1999","relationship":"same-class"},{"drugId":"ibutilide","brandName":"ibutilide","genericName":"ibutilide","approvalYear":"1995","relationship":"same-class"},{"drugId":"dronedarone","brandName":"dronedarone","genericName":"dronedarone","approvalYear":"2009","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT00126022","phase":"PHASE3","title":"Intravenous Tedisamil in the Rapid Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm in Female Subjects","status":"COMPLETED","sponsor":"Solvay Pharmaceuticals","startDate":"2004-12","conditions":["Atrial Fibrillation","Atrial Flutter"],"enrollment":0,"completionDate":"2006-03"},{"nctId":"NCT00126074","phase":"PHASE3","title":"Intravenous Tedisamil in the Rapid Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm in Female Subjects","status":"COMPLETED","sponsor":"Solvay Pharmaceuticals","startDate":"2004-10","conditions":["Atrial Fibrillation","Atrial Flutter"],"enrollment":0,"completionDate":"2006-03"},{"nctId":"NCT00126061","phase":"PHASE3","title":"Intravenous Tedisamil in the Rapid Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm in Male Subjects","status":"COMPLETED","sponsor":"Solvay Pharmaceuticals","startDate":"2004-10","conditions":["Atrial Fibrillation","Atrial Flutter"],"enrollment":0,"completionDate":"2006-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"A5VAY2U3R8","CHEBI":"CHEBI:134747","INN_ID":"6297","UMLSCUI":"C0076034","ChEMBL_ID":"CHEMBL2111110","KEGG_DRUG":"D06652","DRUGBANK_ID":"DB06200","PUBCHEM_CID":"65825","SNOMEDCT_US":"713431000","IUPHAR_LIGAND_ID":"2567","SECONDARY_CAS_RN":"150501-62-5","MESH_SUPPLEMENTAL_RECORD_UI":"C059921"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":102,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01BD06","allCodes":["C01BD06"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"TEDISAMIL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}