{"id":"technetium-99mtc-methylenediphosphonate-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Radiation exposure"},{"rate":null,"effect":"Allergic reaction to technetium complex"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"The methylenediphosphonate (MDP) moiety has a high affinity for hydroxyapatite in bone mineral, allowing the technetium-99m radionuclide to accumulate in areas of increased osteogenesis and blood flow. This enables gamma camera imaging to visualize bone lesions, fractures, infections, and metabolic abnormalities. The radioisotope emits gamma radiation that is detected to create diagnostic images of skeletal pathology.","oneSentence":"Technetium-99m methylenediphosphonate is a radiopharmaceutical that binds to bone mineral and is used for skeletal scintigraphy to detect areas of altered bone metabolism.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:37:50.869Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skeletal scintigraphy for detection of bone metastases"},{"name":"Evaluation of bone infections (osteomyelitis)"},{"name":"Assessment of fractures and stress injuries"},{"name":"Evaluation of metabolic bone disease"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["99mTc-MDP Injection"],"phase":"phase_3","status":"active","brandName":"Technetium[99mTc] Methylenediphosphonate Injection","genericName":"Technetium[99mTc] Methylenediphosphonate Injection","companyName":"HTA Co., Ltd.","companyId":"hta-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Technetium-99m methylenediphosphonate is a radiopharmaceutical that binds to bone mineral and is used for skeletal scintigraphy to detect areas of altered bone metabolism. Used for Skeletal scintigraphy for detection of bone metastases, Evaluation of bone infections (osteomyelitis), Assessment of fractures and stress injuries.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}