{"id":"tea-tree-oil-vagitories","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Vaginal discomfort"}]},"_chembl":null,"_fixedAt":"2026-03-30T12:26:19.627038","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tea tree oil contains terpineol and other volatile compounds with documented antimicrobial activity against bacteria, fungi, and some viruses. When formulated as vaginal suppositories, these compounds are released locally to reduce pathogenic microorganisms and modulate local inflammatory responses. The mechanism is primarily antimicrobial rather than receptor-mediated.","oneSentence":"Tea tree oil vagitories deliver antimicrobial and anti-inflammatory compounds directly to vaginal tissue to treat infections and inflammation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:38:28.698Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal infections (bacterial vaginosis, candidiasis, trichomoniasis)"},{"name":"Vaginal inflammation and irritation"}]},"_fixedFields":["pubmed(1)"],"trialDetails":[{"nctId":"NCT04558697","phase":"PHASE4","title":"Use of Vagitories Based on St. John's Wort, Tea Tree Oil and Shepherd's Purse in the Treatment of Vaginal Inflammation","status":"COMPLETED","sponsor":"University of Sarajevo","startDate":"2019-03-21","conditions":"Non Specific Vaginitis","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"recentPublications":[{"date":"2021 Feb 1","pmid":"33269580","title":"Efficacy and safety of three plant extracts based formulations of vagitories in the treatment of vaginitis: a randomized controlled trial.","journal":"Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tea tree oil vagitories","genericName":"Tea tree oil vagitories","companyName":"University of Sarajevo","companyId":"university-of-sarajevo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tea tree oil vagitories deliver antimicrobial and anti-inflammatory compounds directly to vaginal tissue to treat infections and inflammation. Used for Vaginal infections (bacterial vaginosis, candidiasis, trichomoniasis), Vaginal inflammation and irritation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}