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TCAs also have anticholinergic and antihistamine properties that contribute to their clinical effects.","oneSentence":"TCA inhibits the reuptake of norepinephrine and serotonin in the central nervous system, increasing their synaptic availability.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:38:23.799Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Chronic pain conditions (neuropathic pain, fibromyalgia)"},{"name":"Anxiety disorders"}]},"trialDetails":[{"nctId":"NCT07369531","phase":"NA","title":"The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-preserving Surgery","status":"RECRUITING","sponsor":"The First Hospital of Jilin University","startDate":"2026-03-18","conditions":"Rectal Cancer, Surgical Anastomosis, Survival , Tumor","enrollment":520},{"nctId":"NCT03844412","phase":"PHASE2","title":"Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments","status":"COMPLETED","sponsor":"Duke University","startDate":"2019-11-04","conditions":"Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome","enrollment":209},{"nctId":"NCT07411807","phase":"NA","title":"Study of the Effectiveness of a Systematic Minimal Early Intervention on Care Engagement in Adults With Eating Disorders Requesting Specialized Treatment.","status":"RECRUITING","sponsor":"Centre Hospitalier St Anne","startDate":"2025-12-29","conditions":"Eating Disorders","enrollment":215},{"nctId":"NCT07393919","phase":"PHASE4","title":"Discontination of Antidepressants in Remitted Depression","status":"NOT_YET_RECRUITING","sponsor":"Universita di Verona","startDate":"2026-02-01","conditions":"Depression - 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