{"id":"tazarotene-fabior","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Skin irritation"},{"rate":"5-10%","effect":"Dry skin"},{"rate":"5-10%","effect":"Redness"}]},"_chembl":{"chemblId":"CHEMBL1657","moleculeType":"Small molecule","molecularWeight":"351.47"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by binding to retinoic acid receptors, which are nuclear receptors that regulate gene expression. This leads to changes in the expression of genes involved in cell proliferation and differentiation, ultimately resulting in the reduction of acne lesions and the improvement of skin texture.","oneSentence":"Tazarotene is a topical retinoid that modulates the expression of genes involved in cell proliferation and differentiation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:37:31.967Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Psoriasis"}]},"trialDetails":[{"nctId":"NCT02267746","phase":"PHASE3","title":"A Study To Evaluate The Safety And Therapeutic Equivalence of Tazarotene Foam 0.1% in Subjects With Acne Vulgaris","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2014-06","conditions":"Acne Vulgaris","enrollment":893}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Tazarotene (Fabior™)","genericName":"Tazarotene (Fabior™)","companyName":"Actavis Inc.","companyId":"actavis-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tazarotene is a topical retinoid that modulates the expression of genes involved in cell proliferation and differentiation. Used for Acne vulgaris, Psoriasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}