{"id":"tazarotene-actavis","safety":{"commonSideEffects":[{"rate":"20-40","effect":"Skin irritation (erythema, burning, peeling)"},{"rate":"10-20","effect":"Photosensitivity"},{"rate":"10-15","effect":"Pruritus"},{"rate":null,"effect":"Teratogenicity (pregnancy category X)"}]},"_chembl":{"chemblId":"CHEMBL1657","moleculeType":"Small molecule","molecularWeight":"351.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a third-generation retinoid, tazarotene selectively activates RAR and RXR nuclear receptors, which modulate transcription of genes involved in cell proliferation, differentiation, and inflammation. This mechanism reduces hyperkeratinization and inflammatory responses in the skin, making it effective for treating disorders characterized by abnormal keratinocyte proliferation and differentiation.","oneSentence":"Tazarotene is a retinoid that binds to retinoid X receptors (RXR) and retinoid acid receptors (RAR) to regulate gene expression and promote skin cell differentiation and turnover.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:53:50.107Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Psoriasis"},{"name":"Acne"},{"name":"Photoaging"}]},"trialDetails":[{"nctId":"NCT02267746","phase":"PHASE3","title":"A Study To Evaluate The Safety And Therapeutic Equivalence of Tazarotene Foam 0.1% in Subjects With Acne Vulgaris","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2014-06","conditions":"Acne Vulgaris","enrollment":893}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Tazarotene (Actavis)","genericName":"Tazarotene (Actavis)","companyName":"Actavis Inc.","companyId":"actavis-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tazarotene is a retinoid that binds to retinoid X receptors (RXR) and retinoid acid receptors (RAR) to regulate gene expression and promote skin cell differentiation and turnover. Used for Psoriasis, Acne, Photoaging.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}