{"id":"tazanolast","rwe":[{"pmid":"9603134","year":"1998","title":"Tazanolast inhibits ozone-induced airway hyperresponsiveness in guinea pigs.","finding":"","journal":"American journal of respiratory and critical care medicine","studyType":"Clinical Study"},{"pmid":"9150859","year":"1997","title":"Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"9068982","year":"1997","title":"Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract.","finding":"","journal":"General pharmacology","studyType":"Clinical Study"},{"pmid":"8702244","year":"1996","title":"Effects of antiallergic drugs on the proliferation of estrogen-sensitive mouse Leydig cell line.","finding":"","journal":"Anticancer research","studyType":"Clinical Study"},{"pmid":"1280089","year":"1992","title":"[Effect of tazanolast on platelet activating factor-induced airway hyperresponsiveness in guinea pigs].","finding":"","journal":"Arerugi = [Allergy]","studyType":"Clinical Study"}],"tags":[{"label":"tazanolast","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Allergic conjunctivitis","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tazanol","offLabel":[],"synonyms":["tazanolast","tazalest","tazanol"],"timeline":[],"approvals":[],"brandName":"Tazanol","ecosystem":[{"indication":"Allergic conjunctivitis","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alcaftadine","slug":"alcaftadine","company":"Allergan"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"tazanolast","explanation":"Think of it like a fire alarm in your house. When there's a fire, the alarm goes off to alert you. In allergic conjunctivitis, the 'fire' is an overactive immune response. Tazanolast is like a fire extinguisher that helps turn off the alarm, reducing the symptoms of the allergic reaction.","oneSentence":"Tazanolast works by inhibiting the action of a specific enzyme involved in the allergic response.","technicalDetail":"Tazanolast is a selective inhibitor of the enzyme involved in the production of leukotrienes, which are key mediators of the allergic response in allergic conjunctivitis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2570","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TAZANOLAST","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:48:42.948384","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-21T10:58:34.199089+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"tazanolast","indications":{"approved":[{"name":"Allergic conjunctivitis","source":"DrugCentral","snomedId":473460002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"T0248823H1","CHEBI":"CHEBI:32183","INN_ID":"6264","UMLSCUI":"C0539675","ChEMBL_ID":"CHEMBL564109","KEGG_DRUG":"D01669","PUBCHEM_CID":"5380","MESH_SUPPLEMENTAL_RECORD_UI":"C106301"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"1998 May","pmid":"9603134","title":"Tazanolast inhibits ozone-induced airway hyperresponsiveness in guinea pigs.","journal":"American journal of respiratory and critical care medicine"},{"date":"1997 Apr","pmid":"9150859","title":"Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells.","journal":"Arzneimittel-Forschung"},{"date":"1997 Mar","pmid":"9068982","title":"Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract.","journal":"General pharmacology"},{"date":"1996 May-Jun","pmid":"8702244","title":"Effects of antiallergic drugs on the proliferation of estrogen-sensitive mouse Leydig cell line.","journal":"Anticancer research"},{"date":"1992 Sep","pmid":"1280089","title":"[Effect of tazanolast on platelet activating factor-induced airway hyperresponsiveness in guinea pigs].","journal":"Arerugi = [Allergy]"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tazanol is a small molecule. It is also known by the synonyms TAZANOL and TAZANOLAST.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-21T10:58:34.199089+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}