{"id":"taurolock-u-25000","safety":{"commonSideEffects":[{"rate":null,"effect":"Local catheter site reactions"},{"rate":null,"effect":"Thrombosis"},{"rate":null,"effect":"Infection despite prophylaxis"}]},"_chembl":{"chemblId":"CHEMBL3919361","moleculeType":"Small molecule","molecularWeight":"516.65"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The solution works by coating the internal lumen of central venous catheters with taurolidine, a broad-spectrum antimicrobial agent that disrupts bacterial and fungal biofilms. The addition of heparin prevents thrombosis, while uracil enhances antimicrobial efficacy. This lock therapy is instilled between uses to maintain catheter patency and reduce infection risk in patients requiring long-term central venous access.","oneSentence":"TauroLock U 25000 is an antimicrobial lock solution that prevents biofilm formation and catheter-related bloodstream infections by combining taurolidine with heparin and uracil.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:11:17.552Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of catheter-related bloodstream infections in patients with central venous catheters"},{"name":"Maintenance of central venous catheter patency"}]},"trialDetails":[{"nctId":"NCT02868697","phase":"PHASE4","title":"Management of Tunneled Catheter Thrombosis in Hemodialysis Patients: Prospective Study From Qatar","status":"COMPLETED","sponsor":"Hamad Medical Corporation","startDate":"2013-11","conditions":"Hemodialysis, Tunneled Catheter, Qatar","enrollment":170}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"TauroLock U 25000","genericName":"TauroLock U 25000","companyName":"Hamad Medical Corporation","companyId":"hamad-medical-corporation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TauroLock U 25000 is an antimicrobial lock solution that prevents biofilm formation and catheter-related bloodstream infections by combining taurolidine with heparin and uracil. Used for Prevention of catheter-related bloodstream infections in patients with central venous catheters, Maintenance of central venous catheter patency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}