{"id":"tat","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Systemic immune activation"}]},"_chembl":{"chemblId":"CHEMBL438921","moleculeType":"Small molecule","molecularWeight":"2596.93"},"_dailymed":{"setId":"4cd03bed-99be-e4e8-e063-6294a90a9454","title":"TATTOO NUMBING CREAM (HEMP SEED OIL) CREAM [GUANGZHOU MIZI BIOTECHNOLOGY CO., LTD.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tat (transactivator of transcription) is an HIV regulatory protein that is expressed on the surface of HIV-infected cells. The Tat vaccine aims to induce cellular and humoral immune responses against Tat-expressing cells, potentially controlling viral replication and delaying disease progression. This approach leverages the fact that Tat is essential for HIV replication and is a target of natural immune responses in some long-term non-progressors.","oneSentence":"Tat is a therapeutic vaccine based on the HIV Tat protein designed to boost immune responses against HIV-infected cells.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T03:49:26.011Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV infection (therapeutic vaccine in combination with antiretroviral therapy)"}]},"trialDetails":[{"nctId":"NCT05680948","phase":"","title":"Extended Follow-Up of the ISS T-003 Trial Volunteers (ISS T-003 EF-UP2020)","status":"COMPLETED","sponsor":"Istituto Superiore di Sanità","startDate":"2023-01-25","conditions":"HIV Infections","enrollment":179},{"nctId":"NCT07488754","phase":"NA","title":"Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4)","status":"RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2025-10-01","conditions":"Glioblastoma, High-Grade Glioma (WHO III-IV), Glioblastoma (GBM)","enrollment":35},{"nctId":"NCT05673148","phase":"PHASE3","title":"Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study","status":"RECRUITING","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"2023-10-09","conditions":"Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8","enrollment":364},{"nctId":"NCT06472947","phase":"","title":"Non-invasive Evaluation of Graft Condition in Adult Patients With Kidney Transplant Using Ultrasound Localization Microscopy and Multispectral Optoacoustic Tomography","status":"RECRUITING","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2024-06-18","conditions":"Kidney Transplant, Kidney Biopsy","enrollment":10},{"nctId":"NCT06147037","phase":"PHASE1","title":"A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2024-07-31","conditions":"Advanced Solid Tumor, Metastatic Colorectal Carcinoma, Head and Neck Squamous Cell Carcinoma","enrollment":70},{"nctId":"NCT05488483","phase":"","title":"A Study of Tumor Imaging With Multispectral Optoacoustic Tomography","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2022-07-27","conditions":"Breast Cancer, Melanoma","enrollment":12},{"nctId":"NCT06477003","phase":"NA","title":"Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer","status":"SUSPENDED","sponsor":"University of Oklahoma","startDate":"2026-05","conditions":"Head and Neck Squamous Cell Carcinoma","enrollment":100},{"nctId":"NCT05333978","phase":"NA","title":"Optoacoustic Detection of Inflammation Using MSOT Device","status":"SUSPENDED","sponsor":"University of Oklahoma","startDate":"2022-05-31","conditions":"Graft Vs Host Disease, Colitis, Crohn Disease","enrollment":100},{"nctId":"NCT00748254","phase":"","title":"Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2011-12-01","conditions":"Arthritis, Rheumatoid","enrollment":113},{"nctId":"NCT07347535","phase":"","title":"Non-invasive MSOT Examination of Muscle Oxygenation in Athletes and PAD Patients","status":"NOT_YET_RECRUITING","sponsor":"University Hospital Erlangen","startDate":"2026-01-01","conditions":"PAD - Peripheral Arterial Disease","enrollment":60},{"nctId":"NCT07347938","phase":"","title":"A Phase 4 Study to Evaluate the Effectiveness and Safety of Siltartoxatug Injection for Tetanus Prophylaxis Following Injury","status":"NOT_YET_RECRUITING","sponsor":"Zhuhai Trinomab Pharmaceutical Co., Ltd.","startDate":"2026-01-05","conditions":"Tetanus","enrollment":6000},{"nctId":"NCT06227429","phase":"","title":"A Non-interventional, Post-Marketing Study to Describe Outcome of Nitisinone Treatment in HT-1 Patients","status":"WITHDRAWN","sponsor":"Swedish Orphan Biovitrum","startDate":"2025-09","conditions":"Hereditary Tyrosinemia, Type I","enrollment":""},{"nctId":"NCT04178018","phase":"NA","title":"Transvaginal Ultrasound and Photoacoustic Imaging of Ovary","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2020-02-09","conditions":"Ovary; Anomaly","enrollment":310},{"nctId":"NCT04063020","phase":"","title":"Psychic Stakes of Reconstructive Plastic Surgery in Children With Ear Aplasia","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2020-01-18","conditions":"Ear Aplasia","enrollment":12},{"nctId":"NCT06911749","phase":"NA","title":"MSOT and MRI for Non-invasive Assessment of Intestinal Transit Time in Children With Chronic Bowel Emptying Disorders","status":"RECRUITING","sponsor":"Dr. med. Sonja Diez","startDate":"2025-04-15","conditions":"Chronic Constipation, Slow Transit Constipation, Intestinal Transit Disorder","enrollment":20},{"nctId":"NCT07138768","phase":"","title":"Role of MRI in the Early Diagnosis and Management of Acute Stroke and Its Impact on Turnaround Time in Emergency Settings","status":"RECRUITING","sponsor":"Tanta University","startDate":"2025-08-23","conditions":"Magnetic Resonance Imaging, Diagnosis, Management","enrollment":136},{"nctId":"NCT06579326","phase":"","title":"Photoacoustic Tomography in Assessment of Lower Extremity Artery Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2024-11-01","conditions":"Lower Extremity, Photoacoustic","enrollment":200},{"nctId":"NCT05557331","phase":"NA","title":"Effectiveness of a Mobile App in Reducing Therapeutic TAT in an Emergency Department","status":"RECRUITING","sponsor":"Pediatric Clinical Research Platform","startDate":"2025-03-01","conditions":"Pediatric Emergency Medicine, Therapeutic Turnaround Time","enrollment":18},{"nctId":"NCT07098676","phase":"","title":"Haemodialysis Alters Hypercoagulability of Blood in Dialysis Patients","status":"ENROLLING_BY_INVITATION","sponsor":"Ai Peng","startDate":"2024-11-20","conditions":"Healthy Individuals (Controls), Vascular Surgery Patients With Acute Thrombosis, Dialysis Patients","enrollment":900},{"nctId":"NCT06994260","phase":"","title":"Diagnostic Imaging of Vascular Malformations Using MSOT and ULM","status":"NOT_YET_RECRUITING","sponsor":"University Hospital Erlangen","startDate":"2025-08-01","conditions":"Vascular Malformation, Arteriovenous Malformation, Lymphatic Malformation","enrollment":15},{"nctId":"NCT07021820","phase":"","title":"Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy","status":"RECRUITING","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2025-05-29","conditions":"Centronuclear Myopathy","enrollment":40},{"nctId":"NCT06409884","phase":"NA","title":"Diagnosing Drug Allergy: the T is the Key","status":"RECRUITING","sponsor":"University Hospital, Antwerp","startDate":"2024-05-21","conditions":"Amoxicillin Allergy","enrollment":300},{"nctId":"NCT05952206","phase":"PHASE3","title":"Ischemic and Bleeding Outcomes After Angiolite Stent Implantation and an Abbreviated Dual Antiplatelet Therapy","status":"RECRUITING","sponsor":"iVascular S.L.U.","startDate":"2023-10-13","conditions":"Coronary Artery Disease","enrollment":2312},{"nctId":"NCT06975332","phase":"NA","title":"Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression","status":"RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2024-10-09","conditions":"Glioblastoma, High-Grade Gliomas, Grade III Astrocytoma","enrollment":35},{"nctId":"NCT06966297","phase":"","title":"MSOT_PI Analysis of Revascularization Procedure Using Optoacoustic Imaging","status":"COMPLETED","sponsor":"University Hospital Erlangen","startDate":"2024-03-01","conditions":"PAD, Vascular Diseases","enrollment":40},{"nctId":"NCT06617364","phase":"NA","title":"MSOT for Assessment of Intestinal Transit Time in Lactose Intolerance Patients","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2024-11-11","conditions":"Lactose Intolerance","enrollment":10},{"nctId":"NCT04456400","phase":"","title":"Enhancing Ultrasound & Photoacoustic for Recognition of Intestinal Abnormalities","status":"TERMINATED","sponsor":"iThera Medical GmbH","startDate":"2021-02-03","conditions":"Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease","enrollment":200},{"nctId":"NCT05083806","phase":"NA","title":"MSOT in Pompe Disease","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2022-05-17","conditions":"Pompe Disease, Pompe Disease (Late-onset), Pompe's Disease Juvenile Onset","enrollment":20},{"nctId":"NCT06409169","phase":"NA","title":"DBS TaT in Peer-assisted Telemedicine for Hepatitis C","status":"RECRUITING","sponsor":"Oregon Health and Science University","startDate":"2025-01-22","conditions":"Hepatitis C","enrollment":141},{"nctId":"NCT04185337","phase":"EARLY_PHASE1","title":"Ultrasound-Guided Photoacoustic Imaging for the Detection of Metastases in Inguinal Lymph Nodes","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2021-01-26","conditions":"Malignant Neoplasm","enrollment":23},{"nctId":"NCT06441123","phase":"","title":"Development of a New Family of HIV Latency Regulators (LRAs) Targeting the Tat Viral Protein","status":"RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2025-02-10","conditions":"HIV Infections","enrollment":24},{"nctId":"NCT05869591","phase":"PHASE2","title":"DOAC in Patients with Child a or B Liver Cirrhosis","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire Vaudois","startDate":"2024-01-18","conditions":"Liver Cirrhosis","enrollment":40},{"nctId":"NCT06438965","phase":"","title":"MSOT as Non-invasive Biomarker for Diagnosis and Monitoring of Neuromuscular Diseases","status":"RECRUITING","sponsor":"Children's Hospital of Eastern Ontario","startDate":"2025-02-07","conditions":"Neuromuscular Diseases","enrollment":240},{"nctId":"NCT06740175","phase":"NA","title":"The Feasibility of Multispectral Optoacoustic Tomography in Different Diseases","status":"COMPLETED","sponsor":"University Medical Center Groningen","startDate":"2020-04-07","conditions":"Sjogren Syndrome, Malignant Tumors, Arterial Disease","enrollment":20},{"nctId":"NCT06716892","phase":"","title":"Non-invasive Preoperative Tissue Evaluation in Head and Neck Tumor Patients Using Multispectral Optoacoustic Tomography (MSOT)","status":"RECRUITING","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2024-11-28","conditions":"Head and Neck Cancer, Healthy","enrollment":40},{"nctId":"NCT06645353","phase":"","title":"Evaluation of Perfusion and Oxygenation in Muscle of Patients With PAD Undergoing LER","status":"NOT_YET_RECRUITING","sponsor":"Medical University of Graz","startDate":"2024-11","conditions":"Peripheral Arterial Disease","enrollment":55},{"nctId":"NCT06541496","phase":"","title":"Influence of Fitzpatrick Skin Phototype and Body Mass Index on Non-invasive Optoacoustic Imaging","status":"RECRUITING","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2024-06-14","conditions":"Healthy","enrollment":130},{"nctId":"NCT06399367","phase":"","title":"Investigation of Lipedema, Lymphedema and Vascular Malformations by Multispectral Optoacoustic Tomography (MSOT)","status":"ENROLLING_BY_INVITATION","sponsor":"University Hospital Goettingen","startDate":"2024-08","conditions":"Lipedema, Lymphedema, Vascular Malformations","enrollment":100},{"nctId":"NCT06391346","phase":"NA","title":"Investigation of the Perfusion of Gluteal Muscle in Patients With Intermittent Gluteal Claudication by Non-invasive MSOT","status":"RECRUITING","sponsor":"Ulrich Rother","startDate":"2023-06-23","conditions":"Peripheral Vascular Diseases, Peripheral Arterial Disease, Intermittent Claudication","enrollment":20},{"nctId":"NCT06379126","phase":"","title":"The Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced Coagulopathy","status":"NOT_YET_RECRUITING","sponsor":"The First Hospital of Jilin University","startDate":"2024-04-20","conditions":"Sepsis-induced Coagulopathy","enrollment":210},{"nctId":"NCT06027411","phase":"","title":"Assess the Clinical Effectiveness in AI Prioritising CT Heads","status":"RECRUITING","sponsor":"Guy's and St Thomas' NHS Foundation Trust","startDate":"2024-03-27","conditions":"Trauma, Brain, Mass Lesion, Skull Fractures","enrollment":16800},{"nctId":"NCT04263207","phase":"","title":"Observational Study for the Evaluation of the Role of HIV-1 Tat Protein and Anti-Tat Immune Response In HIV Reservoir","status":"SUSPENDED","sponsor":"Barbara Ensoli, MD, PhD","startDate":"2020-02-04","conditions":"HIV/AIDS","enrollment":100},{"nctId":"NCT06107179","phase":"","title":"Monitoring of Pediatric Inflammatory Bowel Diseases Using Multispectral Optoacoustic Tomography","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2024-01-24","conditions":"Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases","enrollment":50},{"nctId":"NCT04365413","phase":"NA","title":"A Feasibility Study for the Use of Multispectral Optoacoustic Tomography in the Detection of Tumors","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2020-07-22","conditions":"Solid Tumor","enrollment":54},{"nctId":"NCT05933096","phase":"NA","title":"Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Transit","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2023-11-17","conditions":"Gastrointestinal Motility","enrollment":10},{"nctId":"NCT06119438","phase":"NA","title":"Aromatherapy on Pain and Anxiety of the Patients Undergoing Prostate Biopsy","status":"COMPLETED","sponsor":"Mersin Training and Research Hospital","startDate":"2020-01-01","conditions":"Aromatherapy, Prostate Cancer, Anxiety","enrollment":120},{"nctId":"NCT06063785","phase":"","title":"Multispectral Optoacoustic Tomography in Patients With Cystic Fibrosis","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2023-10-01","conditions":"Cystic Fibrosis, Liver Fibrosis, Gastrointestinal Transport Disorder","enrollment":30},{"nctId":"NCT05935839","phase":"NA","title":"Tissue Changes in Diabetes in Adults and Children Using Multispectral Optoacoustic Tomography.","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2023-07-01","conditions":"Diabetes Mellitus, Type 1, Macroangiopathy","enrollment":30},{"nctId":"NCT05935852","phase":"NA","title":"Contrast-enhanced Multispectral Optoacoustic Tomography for Non-invasive Assessment of Diabetic Gastroparesis","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2023-07-15","conditions":"Diabetic Gastroparesis","enrollment":40},{"nctId":"NCT05902884","phase":"NA","title":"New Biomarkers in Facioscapulohumeral Muscular Dystrophy, Multispectral Optoacoustic Tomography.","status":"UNKNOWN","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2023-06-26","conditions":"FSHD","enrollment":20},{"nctId":"NCT03234114","phase":"PHASE4","title":"Optimal Antithrombotic Therapy for ACS Patients Concomitant With AF and Implanted With New-generation DES (OPTIMA-3, 4)","status":"UNKNOWN","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2018-02-03","conditions":"Acute Coronary Syndrome (ACS), Non-valvular Atrial Fibrillation (NVAF)","enrollment":3746},{"nctId":"NCT04650867","phase":"","title":"Non Invasive Characterization of Pediatric Inflammatory Bowel Diseases Using Multispectral Optoacoustic Tomography","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2021-03-22","conditions":"Crohn's Disease, Ulcerative Colitis, IBD","enrollment":23},{"nctId":"NCT05773534","phase":"","title":"Calf Muscle Perfusion in Patients With Intermittent Claudication by 3D-reconstruction of MSOT (MSOT_IC_3D)","status":"UNKNOWN","sponsor":"Ulrich Rother","startDate":"2022-02-27","conditions":"Diagnostic Imaging, Peripheral Arterial Disease, Intermittent Claudication","enrollment":30},{"nctId":"NCT05773547","phase":"","title":"Investigation of the Learning Effect in the Measurement of Circulation in Calf Muscle Using MSOT","status":"UNKNOWN","sponsor":"University Hospital Erlangen","startDate":"2023-01-17","conditions":"Multispectral Optoacoustic Tomography, Learning Curve, Image Interpretation, Computer-Assisted","enrollment":20},{"nctId":"NCT05593133","phase":"NA","title":"PNF and Gait Training on Balance and Gait in Diabetic Neueopathy Patients","status":"COMPLETED","sponsor":"Riphah International University","startDate":"2021-01-05","conditions":"Diabetic Neuropathies","enrollment":40},{"nctId":"NCT02930018","phase":"PHASE3","title":"Safety and Efficacy of Nerinetide (NA-1) in Subjects Undergoing Endovascular Thrombectomy for Stroke","status":"COMPLETED","sponsor":"NoNO Inc.","startDate":"2017-03-01","conditions":"Stroke, Acute","enrollment":1105},{"nctId":"NCT03899948","phase":"NA","title":"Teacher Anxiety Program for Elementary Students","status":"COMPLETED","sponsor":"UConn Health","startDate":"2018-01-18","conditions":"Anxiety","enrollment":54},{"nctId":"NCT03032198","phase":"NA","title":"\"Clinical Evaluation of Opto-Acoustic Tomography for Detection and Diagnostic Differentiation of Thyroid Nodules\"","status":"TERMINATED","sponsor":"Seno Medical Instruments Inc.","startDate":"2017-12-04","conditions":"Feasibility Study for Thyroid Indication","enrollment":37},{"nctId":"NCT05467137","phase":"PHASE4","title":"Sentinel Lymph Node Detection in Patients With Stage Ib-III Melanoma Using MSOT and ICG","status":"UNKNOWN","sponsor":"University Medical Center Groningen","startDate":"2022-09","conditions":"Melanoma, Stage I, Melanoma, Stage II, Melanoma Stage III","enrollment":10},{"nctId":"NCT05160077","phase":"NA","title":"Optoacoustic Characterization of Postprandial Intestinal Blood Flow","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2021-11-23","conditions":"Digestive System Disease, Inflammatory Bowel Diseases","enrollment":10},{"nctId":"NCT05373927","phase":"","title":"Calf Muscle Perfusion in Patients With Intermittent Claudication by Non-invasive MSOT","status":"UNKNOWN","sponsor":"Ulrich Rother","startDate":"2022-06-20","conditions":"Peripheral Vascular Diseases, Peripheral Arterial Disease, Intermittent Claudication","enrollment":100},{"nctId":"NCT04641091","phase":"","title":"Muscle Perfusion in Patients With PAD by Non-invasive MSOT","status":"COMPLETED","sponsor":"University Hospital Erlangen","startDate":"2020-11-13","conditions":"Peripheral Vascular Disease, Peripheral Arterial Disease","enrollment":220},{"nctId":"NCT05110677","phase":"","title":"Pilot Study of Topographic Imaging of the Calf Muscle in Patients With PAD Using 3D Reconstruction of MSOT Images","status":"UNKNOWN","sponsor":"University Hospital Erlangen","startDate":"2021-11-24","conditions":"Peripheral Vascular Diseases, Peripheral Arterial Disease","enrollment":9},{"nctId":"NCT00107549","phase":"PHASE1","title":"Safety of Recombinant HIV Vaccines in HIV Infected Young Adults on Stable Therapy","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":20},{"nctId":"NCT01266616","phase":"PHASE1","title":"Safety of and Immune Response to an Investigational HIV-1 Vaccine With or Without Interleukin-12 (IL-12) in HIV-1 Infected Adults","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2011-03","conditions":"HIV Infections","enrollment":62},{"nctId":"NCT02654080","phase":"PHASE1","title":"Evaluating the Safety, Tolerability, and Immunogenicity of a Prime-Boost Regimen of HIV-1 Nef/Tat/Vif, Env pDNA Vaccine Delivered Intramuscularly With Electroporation and HIV-1 rVSV envC Vaccine in Healthy, HIV-Uninfected Adults","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2016-03","conditions":"HIV Infections","enrollment":14},{"nctId":"NCT00083603","phase":"PHASE1","title":"Safety of and Immune Response to Two HIV Vaccine Formulations (rMVA-HIV and rFPV-HIV) Alone or in Combination in HIV Uninfected Adults","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2004-09","conditions":"HIV Infections","enrollment":150},{"nctId":"NCT00027365","phase":"PHASE1","title":"An Investigational Combination Vaccine Given to People Who Are Not Infected With HIV","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":84},{"nctId":"NCT02547415","phase":"","title":"Chronic Pain in Children and Adolescents.","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Saint Etienne","startDate":"2015-01-22","conditions":"Pain, Chronic","enrollment":30},{"nctId":"NCT05012501","phase":"","title":"Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients","status":"COMPLETED","sponsor":"The Affiliated Hospital of Qingdao University","startDate":"2020-09-01","conditions":"Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis, Liver Cirrhosis","enrollment":79},{"nctId":"NCT04894357","phase":"","title":"Impact of V106I on Resistance to Doravirine","status":"UNKNOWN","sponsor":"Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental","startDate":"2021-09-01","conditions":"HIV-1-infection","enrollment":50},{"nctId":"NCT04950738","phase":"NA","title":"The Effectiveness of Acupuncture for Complications in Critically Ill Patients","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2021-08-01","conditions":"Delirium, Agitation, Arrhythmia","enrollment":80},{"nctId":"NCT03923881","phase":"NA","title":"MSOT Using Cetuximab-800CW for Detection of Cervical Lymph Node Metastases","status":"UNKNOWN","sponsor":"University Medical Center Groningen","startDate":"2019-04-11","conditions":"Oral Cancer, Lymph Node Metastases","enrollment":20},{"nctId":"NCT03920943","phase":"NA","title":"Temporal Artery Thermometer in Patient Transport: Reliability and Validity.","status":"WITHDRAWN","sponsor":"Ornge Transport Medicine","startDate":"2019-09-01","conditions":"Body Temperature","enrollment":""},{"nctId":"NCT04115475","phase":"NA","title":"New Imaging Biomarkers for Muscular Diseases - Multispectral Optoacoustic Imaging in Spinal Muscular Atrophy","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2019-11-07","conditions":"Muscular Diseases, Spinal Muscular Atrophy","enrollment":20},{"nctId":"NCT03653533","phase":"NA","title":"Evaluation of the Function \"Stop Before Hypoglycemia\" on External Insulin Pump","status":"TERMINATED","sponsor":"ARAIR Assistance","startDate":"2019-01-07","conditions":"Type I Diabetes","enrollment":8},{"nctId":"NCT03979157","phase":"NA","title":"Non-invasive Molecular Imaging of Muscle Structure (MSOT_muscles)","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2019-10-14","conditions":"Muscular Diseases","enrollment":10},{"nctId":"NCT01859325","phase":"PHASE1","title":"Therapeutic Vaccine for HIV","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2013-05-10","conditions":"HIV, Therapeutic Vaccine","enrollment":33},{"nctId":"NCT04262570","phase":"NA","title":"Evaluation of Therapeutic Response in Spinal Muscular Atrophy Using Multispectral Optoacoustic Tomography (MSOT) and Magnetic Resonance Imaging (MRI)","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2020-02-25","conditions":"Muscular Diseases, Spinal Muscular Atrophy","enrollment":10},{"nctId":"NCT03490214","phase":"NA","title":"Non-invasive Imaging of Muscle Structure in Duchenne Muscular Dystrophy Using Multispectral Optoacoustic Tomography","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2018-06-01","conditions":"Duchenne Muscular Dystrophy, Muscular Dystrophies, Muscular Dystrophy, Duchenne","enrollment":20},{"nctId":"NCT02622139","phase":"NA","title":"Multispectral Optoacoustic Tomography (MSOT) for the Evaluation of Disease Activity in Inflammatory Bowel Diseases (IBD)","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2015-11","conditions":"Crohn's Disease, Ulcerative Colitis, IBD","enrollment":344},{"nctId":"NCT04058613","phase":"NA","title":"Effects of Maintaining Steady Albumin Levels (TAT 4) on Survival and Liver Related Complications in Cirrhosis With Ascites","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2019-09-10","conditions":"Liver Cirrhosis","enrollment":304},{"nctId":"NCT03757507","phase":"NA","title":"Investigation of Plaque Instability Using Bevacizumab-800CW and MSOT","status":"UNKNOWN","sponsor":"G.M. van Dam","startDate":"2019-04-10","conditions":"Atherosclerosis, Carotid Stenosis, Fluorescence","enrollment":15},{"nctId":"NCT03501823","phase":"","title":"Development of Photoacoustic Tomography","status":"UNKNOWN","sponsor":"University College, London","startDate":"2018-02-23","conditions":"Cancer, Cardiovascular Diseases","enrollment":27},{"nctId":"NCT03269019","phase":"","title":"Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia","status":"UNKNOWN","sponsor":"Wuhan Asia Heart Hospital","startDate":"2017-11-20","conditions":"Heparin-Induced Thrombocytopenia, Thrombosis, Biomarkers","enrollment":200},{"nctId":"NCT02118168","phase":"","title":"Observational Study for the Extended Follow-up of the Patients Enrolled in the Therapeutic Clinical Trial ISS T-002","status":"COMPLETED","sponsor":"Barbara Ensoli, MD, PhD","startDate":"2013-09","conditions":"HIV Infection","enrollment":93},{"nctId":"NCT03090984","phase":"NA","title":"Evaluation of Contact Phase Activation During Hemodialysis","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2017-05-08","conditions":"End Stage Renal Disease","enrollment":10},{"nctId":"NCT03213015","phase":"NA","title":"Correlation Between the Amplitude of Ankle Dorsiflexion and Occurrence of Patellofemoral Pain Syndrome","status":"COMPLETED","sponsor":"Filipe Abdalla dos Reis","startDate":"2017-01-25","conditions":"Patellofemoral Pain Syndrome","enrollment":67},{"nctId":"NCT02712489","phase":"","title":"A Roll-over Observational Study for the Extended Follow-up of the Volunteers of the ISS T-003 Trial","status":"COMPLETED","sponsor":"Barbara Ensoli, MD, PhD","startDate":"2015-01","conditions":"HIV Infections","enrollment":179},{"nctId":"NCT02457689","phase":"PHASE1, PHASE2","title":"The Safety and Immunogenicity of the DNA-GTU Vaccine Administered to HIV-infected Patients on ART vs Placebo","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2015-07","conditions":"HIV","enrollment":30},{"nctId":"NCT00842621","phase":"","title":"Long Term Effects of Erythrocyte Lysis","status":"COMPLETED","sponsor":"St. Jude Children's Research Hospital","startDate":"2009-03","conditions":"Sickle Cell Disease, Hemolytic Anemia","enrollment":390},{"nctId":"NCT01955057","phase":"","title":"Study of Psychopathological Characteristics of Patient Smoking in Thoracic Oncology","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2013-12","conditions":"Smoking Cessation and Lung Cancer","enrollment":50},{"nctId":"NCT00859261","phase":"NA","title":"Two Dimensional (2D) Silicon Transducer-Compression Plates for Breast Ultrasound","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2009-03","conditions":"Breast Tumor, Breast Cysts","enrollment":21},{"nctId":"NCT01024556","phase":"","title":"Observational Study on Anti-Tat Immune Response in HIV-1-infected HAART-treated Adult Subjects","status":"COMPLETED","sponsor":"Barbara Ensoli, MD","startDate":"2008-03","conditions":"HIV Infection","enrollment":142},{"nctId":"NCT01513135","phase":"PHASE2","title":"A Phase Il of a Therapeutic, Recombinant, Biologically Active HIV-1 Tat Protein Vaccine in HIV-Infected, Anti-Tat Negative, ARV-Treated Adult Volunteers","status":"COMPLETED","sponsor":"Barbara Ensoli, MD","startDate":"2012-03","conditions":"HIV Infections","enrollment":200},{"nctId":"NCT01359800","phase":"","title":"Study to Assess the Seroprevalence of Anti-Tat Antibodies in HIV-infected Patients","status":"COMPLETED","sponsor":"Barbara Ensoli, MD","startDate":"2010-10","conditions":"HIV Infection","enrollment":531},{"nctId":"NCT01029548","phase":"","title":"Observational Study on Anti-Tat Immune Response in HIV-1-infected Asymptomatic Adult Subjects","status":"COMPLETED","sponsor":"Barbara Ensoli, MD","startDate":"2008-04","conditions":"HIV Infections","enrollment":73},{"nctId":"NCT00751595","phase":"PHASE2","title":"Immunogenicity and Safety Trial of the HIV-1 Tat Vaccine","status":"COMPLETED","sponsor":"Barbara Ensoli, MD","startDate":"2008-09","conditions":"HIV Infections","enrollment":168},{"nctId":"NCT01441193","phase":"PHASE1","title":"A Phase I Safety and Immunogenicity Preventive Vaccine Trial Based on the HIV-1 Tat and V2-deleted Env Proteins (ISS P-002)","status":"TERMINATED","sponsor":"Barbara Ensoli, MD","startDate":"2011-09","conditions":"HIV Infection","enrollment":11},{"nctId":"NCT01206933","phase":"","title":"The Effect of HIV Tat Protein on HCV Replication in an In-vitro Model System","status":"COMPLETED","sponsor":"George Washington University","startDate":"2010-07","conditions":"Human Immunodeficiency Virus (HIV), Hepatitis C, Chronic","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17794,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tat","genericName":"Tat","companyName":"Barbara Ensoli, MD","companyId":"barbara-ensoli-md","modality":"Biologic","firstApprovalDate":"","aiSummary":"Tat is a therapeutic vaccine based on the HIV Tat protein designed to boost immune responses against HIV-infected cells. Used for HIV infection (therapeutic vaccine in combination with antiretroviral therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}