{"id":"tartrazine","rwe":[{"pmid":"41903461","year":"2026","title":"Mitigation of tartrazine induced histopathological and genotoxic effects in Coturnix coturnix japonica using green synthesized silver nanoparticles.","finding":"","journal":"Poultry science","studyType":"Clinical Study"},{"pmid":"41879811","year":"2026","title":"Processed Foods and Food Dyes: What Are We Eating and What Is the Cardiovascular Risk?","finding":"","journal":"Cardiology in review","studyType":"Clinical Study"},{"pmid":"41862071","year":"2026","title":"Tartrazine-induced nephrotoxicity via oxidative and genotoxic pathways in rats: Regulatory insights and the nephroprotective role of curcumin.","finding":"","journal":"Regulatory toxicology and pharmacology : RTP","studyType":"Clinical Study"},{"pmid":"41855801","year":"2026","title":"Efficacy of eco-friendly synthesized silver nanoparticles in ameliorating tartrazine induced reproductive toxicity in Japanese quails.","finding":"","journal":"Poultry science","studyType":"Clinical Study"},{"pmid":"41846460","year":"2026","title":"Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS-2B Cells: Viability, Apoptosis, and DNA Damage.","finding":"","journal":"Journal of applied toxicology : JAT","studyType":"Clinical Study"}],"tags":[{"label":"tartrazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Coloring Agents","category":"pharmacology"},{"label":"Food Additives","category":"pharmacology"},{"label":"Food Coloring Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tartrazol yellow","offLabel":[],"synonyms":["tartrazine","tartrazol yellow"],"timeline":[],"approvals":[],"brandName":"Tartrazol Yellow","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"tartrazine","explanation":"Think of it like a key fitting into a lock - tartrazine is like the key that changes the way proteins work, which can affect how our bodies respond to different stimuli. However, the exact way it does this is still not fully understood. It's a bit like a puzzle piece that fits into a larger puzzle, but we don't know what the whole picture looks like.","oneSentence":"Tartrazine works by binding to and altering the activity of certain proteins in the body.","technicalDetail":"Tartrazine is a xanthene dye that acts as a competitive inhibitor of certain enzymes, potentially altering the activity of proteins involved in various biological pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2567","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=tartrazine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tartrazine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:48:30.925137","biosimilars":[],"competitors":[],"genericName":"tartrazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06800183","phase":"EARLY_PHASE1","title":"Topical Tartrazine for Improved Skin Structure Visualization in Dermatology","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2026-05-11","conditions":["Healthy","Dermoscopy","Optical Imaging"],"enrollment":0,"completionDate":"2026-12"},{"nctId":"NCT06984640","phase":"NA","title":"Curcumin Supplementation for the Improvement of Diabetes-related Outcomes","status":"COMPLETED","sponsor":"Oklahoma State University","startDate":"2023-03-16","conditions":["Over Age 60","Prediabetes or Overweight"],"enrollment":28,"completionDate":"2025-02-13"},{"nctId":"NCT04590196","phase":"EARLY_PHASE1","title":"Effect of Oral Curcumin Supplementation in Dry Age-related Macular Degeneration (AMD) Patients","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2020-11-01","conditions":["Age Related Macular Degeneration"],"enrollment":10,"completionDate":"2023-06-01"},{"nctId":"NCT00681538","phase":"PHASE3","title":"A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)","status":"COMPLETED","sponsor":"Jazz 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Pharmaceuticals","startDate":"2014-09","conditions":["Cancer"],"enrollment":21,"completionDate":"2016-06"},{"nctId":"NCT03818321","phase":"PHASE2","title":"Urinary Track Infection Prevention After Urogynecological Surgery","status":"COMPLETED","sponsor":"TriHealth Inc.","startDate":"2019-06-17","conditions":["Urinary Tract Infections","Urinary Retention Postoperative","Pelvic Organ Prolapse"],"enrollment":185,"completionDate":"2021-07-01"},{"nctId":"NCT04596722","phase":"NA","title":"Oral Pomegranate Extract on the Microbiome and Skin Biophysical Properties","status":"COMPLETED","sponsor":"Integrative Skin Science and Research","startDate":"2020-11-09","conditions":["Human Microbiome"],"enrollment":18,"completionDate":"2021-03-24"},{"nctId":"NCT03218709","phase":"PHASE4","title":"The Intervention of Multi-vitamin With Minerals to Hyperuricemia","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2017-01","conditions":["Hyperuricemia"],"enrollment":200,"completionDate":"2018-04"},{"nctId":"NCT03200197","phase":"NA","title":"Effectiveness of Menthol Chewing Gum in the Management of Thirst","status":"COMPLETED","sponsor":"Universidade Estadual de Londrina","startDate":"2016-11","conditions":["Thirst"],"enrollment":102,"completionDate":"2017-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000022694","MMSL":"NOCODE","NDDF":"008923","UNII":"6TP696149N","VUID":"4020156","CHEBI":"CHEBI:9405","VANDF":"4018441","RXNORM":"1305578","UMLSCUI":"C0039329","PUBCHEM_CID":"164825","MESH_DESCRIPTOR_UI":"D013645"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":929,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 13","pmid":"41903461","title":"Mitigation of tartrazine induced histopathological and genotoxic effects in Coturnix coturnix japonica using green synthesized silver nanoparticles.","journal":"Poultry science"},{"date":"2026 Mar 25","pmid":"41879811","title":"Processed Foods and Food Dyes: What Are We Eating and What Is the Cardiovascular Risk?","journal":"Cardiology in review"},{"date":"2026 Mar 18","pmid":"41862071","title":"Tartrazine-induced nephrotoxicity via oxidative and genotoxic pathways in rats: Regulatory insights and the nephroprotective role of curcumin.","journal":"Regulatory toxicology and pharmacology : RTP"},{"date":"2026 Mar 12","pmid":"41855801","title":"Efficacy of eco-friendly synthesized silver nanoparticles in ameliorating tartrazine induced reproductive toxicity in Japanese quails.","journal":"Poultry science"},{"date":"2026 Mar 18","pmid":"41846460","title":"Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS-2B Cells: Viability, Apoptosis, and DNA Damage.","journal":"Journal of applied toxicology : 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It is also known by other names such as Tartrazine, C.I. 19140, FD&C Yellow 5, and Yellow 5 Lake.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}