{"id":"tapentadol-oxycodone","brandName":"tapentadol, oxycodone","genericName":"tapentadol, oxycodone","companyId":"university-hospital-schleswig-holstein","companyName":"University Hospital Schleswig-Holstein","phase":"marketed","status":"active","modality":"Small molecule","aliases":["Palexia"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Tapentadol and oxycodone are opioid analgesics used for moderate to severe pain management. Tapentadol has a dual mechanism of action, targeting both μ-opioid receptors and norepinephrine reuptake. Oxycodone primarily acts on μ-opioid receptors. Both drugs have been studied in various pain conditions, including postoperative and neuropathic pain, with tapentadol showing potential advantages in certain settings.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both drugs are mu-opioid receptor agonists that work by binding to opioid receptors in the brain and spinal cord, thereby decreasing pain signal transmission. Tapentadol has a dual mechanism, combining mu-opioid agonism with norepinephrine reuptake inhibition, which may enhance analgesia through multiple pathways. Oxycodone acts primarily through mu-opioid receptor activation.","oneSentence":"Tapentadol and oxycodone are opioid analgesics that bind to mu-opioid receptors in the central nervous system to reduce pain perception; tapentadol also inhibits norepinephrine reuptake.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"20-40","effect":"Nausea"},{"rate":"15-30","effect":"Dizziness"},{"rate":"20-40","effect":"Constipation"},{"rate":"15-25","effect":"Somnolence"},{"rate":"10-20","effect":"Vomiting"},{"rate":"5-15","effect":"Headache"},{"rate":null,"effect":"Respiratory depression"}]},"trials":[],"indications":{"approved":[{"name":"Moderate to severe acute pain"},{"name":"Moderate to severe chronic pain"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}