{"id":"tap-block-and-dexamethasone-i-v","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Hypertension"},{"rate":"5-10%","effect":"Nausea and vomiting"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Insomnia"}]},"_chembl":{"chemblId":"CHEMBL1697787","moleculeType":"Small molecule","molecularWeight":"528.57"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"TAP block involves the injection of local anesthetics into the transversus abdominis plane to block nerve signals that cause shivering. Dexamethasone, on the other hand, is a synthetic corticosteroid that can reduce inflammation and suppress the immune system. When used together, they can help reduce the incidence of postoperative shivering and other complications.","oneSentence":"TAP block is a technique used to prevent postoperative shivering, while dexamethasone is a corticosteroid with anti-inflammatory and immunosuppressive properties.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:37:33.591Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of postoperative shivering"}]},"trialDetails":[{"nctId":"NCT04223128","phase":"NA","title":"Comparing Intravenous Magnesium Sulfate With Dexamethasone as Adjuvants to Ultrasound Guided TAPblock","status":"COMPLETED","sponsor":"Tamer Nabil Abdelrahman","startDate":"2019-12-01","conditions":"Postoperative Pain","enrollment":60},{"nctId":"NCT02783144","phase":"PHASE3","title":"Dexamethasone Added in Ultrasound-guided Transversus Abdominis Plain Block for Postoperative Analgesia","status":"COMPLETED","sponsor":"San Salvatore Hospital of L'Aquila","startDate":"2017-06-28","conditions":"Postoperative Pain","enrollment":120},{"nctId":"NCT02073435","phase":"","title":"A2ALL-Patients Safety System Improvements in Living Donor Liver Transplantation","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2010-10","conditions":"Liver Diseases, Hepatocellular Cancer, Endstage Liver Disease","enrollment":177}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TAP-Block under ultrasound guidance and i.v. dexamethasone"],"phase":"phase_3","status":"active","brandName":"TAP Block and Dexamethasone i.v.","genericName":"TAP Block and Dexamethasone i.v.","companyName":"San Salvatore Hospital of L'Aquila","companyId":"san-salvatore-hospital-of-l-aquila","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TAP block is a technique used to prevent postoperative shivering, while dexamethasone is a corticosteroid with anti-inflammatory and immunosuppressive properties. Used for Prevention of postoperative shivering.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}