{"id":"tandospirone-amlodipine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL1200402","moleculeType":"Small molecule","molecularWeight":"567.06"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a fixed-dose combination where tandospirone selectively binds to serotonin 5-HT1A receptors in the brain to reduce anxiety symptoms, while amlodipine blocks L-type calcium channels in vascular smooth muscle and cardiac tissue to lower blood pressure and improve coronary blood flow. The combination addresses both anxiety and cardiovascular conditions in a single formulation.","oneSentence":"Tandospirone acts as a 5-HT1A receptor agonist for anxiety, while amlodipine is a calcium channel blocker for hypertension and angina.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:11:04.591Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Generalized anxiety disorder"},{"name":"Hypertension"},{"name":"Angina pectoris"}]},"trialDetails":[{"nctId":"NCT03667677","phase":"PHASE4","title":"Comparison of Tandospirone, Amlodipine and Their Combination in Adults With Hypertension and Anxiety","status":"UNKNOWN","sponsor":"Chongqing Medical University","startDate":"2019-02-01","conditions":"Hypertension, Anxiety","enrollment":256}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tandospirone + Amlodipine","genericName":"Tandospirone + Amlodipine","companyName":"Chongqing Medical University","companyId":"chongqing-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tandospirone acts as a 5-HT1A receptor agonist for anxiety, while amlodipine is a calcium channel blocker for hypertension and angina. Used for Generalized anxiety disorder, Hypertension, Angina pectoris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}