{"id":"tandospirone","rwe":[{"pmid":"41784801","year":"2026","title":"Acute apocynin-tandospirone derivatives (ATDs) exacerbate methamphetamine-induced hyperlocomotion in rats.","finding":"","journal":"Psychopharmacology","studyType":"Clinical Study"},{"pmid":"41733174","year":"2026","title":"Assessment of Off-Label Psychotropic Drug Use in Children and Adolescents: A Multi-Center Cross-Sectional Study in China.","finding":"","journal":"Pharmacoepidemiology and drug safety","studyType":"Clinical Study"},{"pmid":"41500315","year":"2026","title":"Efficacy of escitalopram plus tandospirone in treating vascular depressive mood disorder: A 12-week single-center randomized controlled trial.","finding":"","journal":"Journal of affective disorders","studyType":"Clinical Study"},{"pmid":"41422207","year":"2025","title":"Psychotic major depressive disorder and rapid eye movement sleep behavior disorder cooccurring with a pineal cyst: a case report with neuroimaging insights in a 15-year-old female.","finding":"","journal":"BMC psychiatry","studyType":"Clinical Study"},{"pmid":"41249389","year":"2025","title":"Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients.","finding":"","journal":"NPJ digital medicine","studyType":"Clinical Study"}],"tags":[{"label":"tandospirone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(4) dopamine receptor","category":"target"},{"label":"DRD4","category":"gene"},{"label":"DRD2","category":"gene"},{"label":"HTR1A","category":"gene"},{"label":"Active","category":"status"},{"label":"Bruxism (teeth grinding)","category":"indication"},{"label":"Anti-Anxiety Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Serotonin Agents","category":"pharmacology"},{"label":"Serotonin Receptor Agonists","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"metanopirone citrate","offLabel":[],"synonyms":["tandospirone","tandospirone citrate","metanopirone citrate"],"timeline":[],"approvals":[],"brandName":"Metanopirone Citrate","ecosystem":[{"indication":"Bruxism (teeth grinding)","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"D(4) dopamine receptor","targets":[{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine receptor","protein":"D(4) dopamine receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"HTR1A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1A","protein":"5-hydroxytryptamine receptor 1A"}],"modality":"Small Molecule","drugClass":"tandospirone","explanation":"Imagine your brain is like a city with many different streets and intersections. 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