{"id":"tamsulosine-arrow-lp","safety":{"commonSideEffects":[{"rate":"8-18","effect":"Retrograde ejaculation"},{"rate":"2-5","effect":"Dizziness"},{"rate":"1-3","effect":"Headache"},{"rate":"1-3","effect":"Asthenia/fatigue"},{"rate":"0.5-2","effect":"Orthostatic hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tamsulosin selectively blocks alpha-1A adrenergic receptors located on smooth muscle cells in the prostate gland and bladder neck. By antagonizing these receptors, it reduces smooth muscle tone and tension in these tissues, thereby decreasing urinary obstruction and improving urinary symptoms associated with benign prostatic hyperplasia. The LP (long-acting) formulation provides sustained drug release for once-daily dosing.","oneSentence":"Tamsulosin is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:11:02.848Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Benign prostatic hyperplasia with lower urinary tract symptoms"}]},"trialDetails":[{"nctId":"NCT01604811","phase":"PHASE4","title":"Exploratory Study of L.S.E.S.r. (LipidoSterolic Extract of Serenoa Repens)(PERMIXON® 160 mg Hard Capsule) Versus Tamsulosine LP Activity on Inflammation Biomarkers in Urinary Symptoms Related to BPH (Benign Prostatic Hyperplasia)","status":"COMPLETED","sponsor":"Pierre Fabre Medicament","startDate":"2012-06","conditions":"Benign Prostatic Hyperplasia (BPH)","enrollment":206}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tamsulosine Arrow LP","genericName":"Tamsulosine Arrow LP","companyName":"Pierre Fabre Medicament","companyId":"pierre-fabre-medicament","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tamsulosin is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow. Used for Benign prostatic hyperplasia with lower urinary tract symptoms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}