{"id":"taltirelin","rwe":[{"pmid":"41809083","year":"2026","title":"Effects of nucleation on solvate and polymorph control - evaporative crystallization of taltirelin.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"41714866","year":"2026","title":"Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration.","finding":"","journal":"Journal of movement disorders","studyType":"Clinical Study"},{"pmid":"41613766","year":"2026","title":"JAK4D, a first-in-class thyrotropin-releasing hormone analogue, reverses scopolamine-induced memory deficits.","finding":"","journal":"Brain communications","studyType":"Clinical Study"},{"pmid":"41330489","year":"2026","title":"Taltirelin treatment alleviates PTSD-like symptoms and restores neural oscillations in male mice receiving single prolonged stress.","finding":"","journal":"Neuropharmacology","studyType":"Clinical Study"},{"pmid":"39736794","year":"2024","title":"Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons.","finding":"","journal":"Journal of translational medicine","studyType":"Clinical Study"}],"tags":[{"label":"taltirelin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Thyrotropin-releasing hormone receptor","category":"target"},{"label":"TRHR","category":"gene"},{"label":"Active","category":"status"},{"label":"Spinocerebellar disease","category":"indication"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Nootropic Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ceredist","offLabel":[],"synonyms":["taltirelin hydrate","ceredist","taltirelin tetrahydrate","TA-0910","TA 0910","taltirelin"],"timeline":[],"approvals":[],"brandName":"Ceredist","ecosystem":[{"indication":"Spinocerebellar disease","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Thyrotropin-releasing hormone receptor","targets":[{"gene":"TRHR","source":"DrugCentral","target":"Thyrotropin-releasing hormone receptor","protein":"Thyrotropin-releasing hormone receptor"}],"modality":"Small Molecule","drugClass":"taltirelin","explanation":"Imagine your body has a system that controls how different parts work together. Ceredist helps to fine-tune this system by blocking or enhancing signals that are sent between different parts of the body. This can help to slow down or stop the progression of certain diseases.","oneSentence":"Ceredist works by binding to the thyrotropin-releasing hormone receptor, which helps to regulate certain bodily functions.","technicalDetail":"Ceredist (Taltirelin) acts as a thyrotropin-releasing hormone receptor agonist, which means it binds to and activates the thyrotropin-releasing hormone receptor, leading to a cascade of downstream effects that can help to treat spinocerebellar disease."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2560","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TALTIRELIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TALTIRELIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:46:42.185743","biosimilars":[],"competitors":[{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"protirelin","drugSlug":"protirelin","fdaApproval":"1976-11-05","patentStatus":"Unknown","relationship":"same-target"}],"genericName":"taltirelin","indications":{"approved":[{"name":"Spinocerebellar disease","source":"DrugCentral","snomedId":91502009,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-target"},{"drugId":"protirelin","brandName":"protirelin","genericName":"protirelin","approvalYear":"1976","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT04107740","phase":"PHASE4","title":"C-Trelin Orally Disintegrated(OD) Tablet 5mg in Ataxia Due to Spinocerebellar Degeneration","status":"COMPLETED","sponsor":"HLB Pharmaceutical Co., Ltd.","startDate":"2019-03-04","conditions":["Spinocerebellar Degeneration"],"enrollment":160,"completionDate":"2021-02-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"DOZ62MV6A5","CHEBI":"CHEBI:135653","INN_ID":"7503","UMLSCUI":"C2960839","ChEMBL_ID":"CHEMBL2107016","KEGG_DRUG":"D01925","PUBCHEM_CID":"114750","IUPHAR_LIGAND_ID":"2143","SECONDARY_CAS_RN":"201677-75-0","MESH_SUPPLEMENTAL_RECORD_UI":"C065049"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":65,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 9","pmid":"41809083","title":"Effects of nucleation on solvate and polymorph control - evaporative crystallization of taltirelin.","journal":"RSC advances"},{"date":"2026 Feb 20","pmid":"41714866","title":"Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration.","journal":"Journal of movement disorders"},{"date":"2026","pmid":"41613766","title":"JAK4D, a first-in-class thyrotropin-releasing hormone analogue, reverses scopolamine-induced memory deficits.","journal":"Brain communications"},{"date":"2026 Feb 15","pmid":"41330489","title":"Taltirelin treatment alleviates PTSD-like symptoms and restores neural oscillations in male mice receiving single prolonged stress.","journal":"Neuropharmacology"},{"date":"2024 Dec 30","pmid":"39736794","title":"Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons.","journal":"Journal of translational medicine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Recombinant protein","firstApprovalDate":"","aiSummary":"Ceredist is a thyrotropin-releasing hormone receptor agonist that acts on the thyrotropin-releasing hormone receptor, a protein target. It is classified as a drug in the agonist class, with synonyms including TA-0910, TALTIRELIN, TALTIRELINA, and TALTIRELINE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}