{"id":"talc-powder","safety":{"commonSideEffects":[{"rate":null,"effect":"Chest pain or abdominal pain"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Dyspnea"},{"rate":null,"effect":"Talcosis (chronic lung inflammation from inhalation)"}]},"_chembl":null,"_dailymed":{"setId":"3380263d-ee7b-4946-a467-35a24789a901","title":"MICONAZOLE NITRATE (ATHLETES FOOT POWDER SPRAY TALC FREE) AEROSOL, POWDER [CVS PHARMACY]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"When instilled into body cavities (pleural, peritoneal, or pericardial), talc particles trigger an inflammatory response that leads to fibrosis and adhesion of the visceral and parietal surfaces. This mechanical obliteration of the space prevents malignant effusions from reaccumulating. The mechanism is primarily physical and inflammatory rather than pharmacological.","oneSentence":"Talc powder acts as a sclerosing agent that causes inflammation and adhesion of serosal surfaces to prevent fluid reaccumulation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:48:58.980Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malignant pleural effusion"},{"name":"Malignant peritoneal effusion"},{"name":"Malignant pericardial effusion"}]},"trialDetails":[{"nctId":"NCT07167992","phase":"NA","title":"Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis","status":"NOT_YET_RECRUITING","sponsor":"University of Health Sciences Lahore","startDate":"2026-02-01","conditions":"Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion, Malignant","enrollment":160},{"nctId":"NCT06464536","phase":"NA","title":"Evaluation of the Efficacy of Compression With Tight Surgical Gloves in Patients With Taxane-based Therapy","status":"RECRUITING","sponsor":"St.Gallen University of Applied Sciences","startDate":"2025-02-03","conditions":"Taxane-induced Peripheral Neuropathy","enrollment":114},{"nctId":"NCT06883188","phase":"PHASE2, PHASE3","title":"Stop Air Leak by Talc or Autologous Blood Patch Therapy","status":"NOT_YET_RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2026-04-01","conditions":"Pneumothorax Spontaneous Secondary","enrollment":30},{"nctId":"NCT05576038","phase":"NA","title":"Tryptophan for Impaired AhR Signaling in Celiac Disease","status":"RECRUITING","sponsor":"McMaster University","startDate":"2022-12-01","conditions":"Tryptophan Metabolism Alterations, Celiac Disease","enrollment":50},{"nctId":"NCT06333158","phase":"PHASE4","title":"Extracts of Amla, Walnut Leaf, Red Yeast Rice and Olive in Cardiovascular Prevention","status":"COMPLETED","sponsor":"Nina Hermans","startDate":"2024-03-22","conditions":"Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia","enrollment":36},{"nctId":"NCT03827070","phase":"PHASE1","title":"Dry Pleurodesis With Talcum and Afatinib is Used to Treat Patients With Non-Small Cell Lung Carcinoma","status":"UNKNOWN","sponsor":"Center Trials & Treatment Europe","startDate":"2019-03-05","conditions":"Non Small Cell Lung Cancer","enrollment":12},{"nctId":"NCT05586295","phase":"NA","title":"Vitamin B Complex Improved Exercise Performance and Anti-fatigue","status":"COMPLETED","sponsor":"National Taiwan Sport University","startDate":"2021-03-03","conditions":"Exercise Performance, Fatigue","enrollment":32},{"nctId":"NCT05421117","phase":"","title":"Comparison of Laparoscopic Adnexal Mass Extraction Via the Transumbilical and Transvaginal Routes","status":"COMPLETED","sponsor":"Erzincan Military Hospital","startDate":"2016-01-01","conditions":"Surgical Procedure, Unspecified","enrollment":93},{"nctId":"NCT02674243","phase":"PHASE3","title":"Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion","status":"COMPLETED","sponsor":"Chiang Mai University","startDate":"2015-11","conditions":"Malignant Pleural Effusion","enrollment":60},{"nctId":"NCT00565266","phase":"PHASE3","title":"Asthma Clinical Research Network (ACRN) Trial - Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC)","status":"COMPLETED","sponsor":"Milton S. Hershey Medical Center","startDate":"2008-05","conditions":"Asthma","enrollment":210},{"nctId":"NCT02809313","phase":"PHASE2","title":"Clinical and Microbiological Effects of Lactobacillus Rhamnosus in Treatment of Gingivitis","status":"UNKNOWN","sponsor":"Jorge Gamonal","startDate":"2016-03","conditions":"Gingivitis","enrollment":36},{"nctId":"NCT02839408","phase":"PHASE2","title":"Efficacy of Oral Probiotic and Antibiotic Administration in Patients With Chronic Periodontitis","status":"UNKNOWN","sponsor":"University of Chile","startDate":"2015-06","conditions":"Chronic Periodontitis","enrollment":54},{"nctId":"NCT02283736","phase":"PHASE2","title":"Efficacy of Oral Probiotic Administration in Patients With Chronic Periodontitis","status":"UNKNOWN","sponsor":"Jorge Gamonal","startDate":"2014-06","conditions":"-Chronic Periodontitis","enrollment":36},{"nctId":"NCT02511600","phase":"PHASE3","title":"Comparison of Progel Sealant to Standard of Care (SOC) for Patients Undergoing Decortication","status":"WITHDRAWN","sponsor":"M.D. Anderson Cancer Center","startDate":"2015-12","conditions":"Lung Diseases, Mesothelioma","enrollment":""},{"nctId":"NCT01211769","phase":"PHASE3","title":"Effects of Omegas 3 and 6 on Alcohol Dependence","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2006-02","conditions":"Alcohol Dependence","enrollment":80}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"CONDITION AGGRAVATED"},{"count":2,"reaction":"COVID-19 PNEUMONIA"},{"count":2,"reaction":"OFF LABEL USE"},{"count":1,"reaction":"ABSCESS"},{"count":1,"reaction":"ACUTE RESPIRATORY DISTRESS SYNDROME"},{"count":1,"reaction":"ANAL PRURITUS"},{"count":1,"reaction":"ANXIETY"},{"count":1,"reaction":"APHTHOUS ULCER"},{"count":1,"reaction":"APPLICATION SITE RASH"},{"count":1,"reaction":"ARTHRALGIA"}],"_approvalHistory":[],"publicationCount":106,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"talc powder","genericName":"talc powder","companyName":"Chinese University of Hong Kong","companyId":"chinese-university-of-hong-kong","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Talc powder acts as a sclerosing agent that causes inflammation and adhesion of serosal surfaces to prevent fluid reaccumulation. Used for Malignant pleural effusion, Malignant peritoneal effusion, Malignant pericardial effusion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}