{"id":"tak-816","safety":{"commonSideEffects":[{"rate":null,"effect":"Increased risk of atrial fibrillation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By inhibiting Nav1.5, TAK-816 is expected to reduce the abnormal electrical activity in the heart that can lead to atrial fibrillation. This mechanism is thought to be effective in preventing stroke in patients with atrial fibrillation.","oneSentence":"TAK-816 is a selective, reversible inhibitor of the sodium-activated potassium channel Nav1.5.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:37:28.180Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrial fibrillation for stroke prevention"}]},"trialDetails":[{"nctId":"NCT02074345","phase":"PHASE3","title":"Phase III Study of Intramuscular TAK-816 in Healthy Infants","status":"COMPLETED","sponsor":"Takeda","startDate":"2014-03","conditions":"Healthy Volunteers, Haemophilus Influenzae Type b, Prevention","enrollment":31},{"nctId":"NCT01379846","phase":"PHASE3","title":"Study of TAK-816 in Healthy Infants","status":"COMPLETED","sponsor":"Takeda","startDate":"2011-06","conditions":"Immunization","enrollment":416}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"TAK-816","genericName":"TAK-816","companyName":"Takeda","companyId":"takeda","modality":"Biologic","firstApprovalDate":"","aiSummary":"TAK-816 is a selective, reversible inhibitor of the sodium-activated potassium channel Nav1.5. Used for Atrial fibrillation for stroke prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}