{"id":"tafenoquine-plus-dha-piperaquine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hemolysis (in G6PD-deficient patients)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tafenoquine is an 8-aminoquinoline that targets hypnozoites (dormant liver forms) of Plasmodium vivax and P. ovale, preventing relapse. DHA-piperaquine is an artemisinin-based combination therapy that rapidly eliminates circulating parasites through multiple mechanisms including oxidative stress and heme polymerization inhibition. Together, they provide complete parasite clearance and relapse prevention.","oneSentence":"This combination uses tafenoquine to eliminate dormant malaria parasites in the liver and piperaquine (in DHA-piperaquine) to kill active blood-stage parasites, providing both curative and preventive antimalarial activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:11:02.849Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plasmodium vivax malaria treatment and relapse prevention"},{"name":"Plasmodium ovale malaria treatment and relapse prevention"}]},"trialDetails":[{"nctId":"NCT07060794","phase":"PHASE4","title":"Tafenoquine and ACTs (TADORE- Plus)","status":"NOT_YET_RECRUITING","sponsor":"Menzies School of Health Research","startDate":"2026-06","conditions":"Vivax Malaria","enrollment":507},{"nctId":"NCT07403643","phase":"PHASE4","title":"Investigating the Pharmacology of Tafenoquine in Papua New Guinean Children With Uncomplicated Malaria","status":"NOT_YET_RECRUITING","sponsor":"Curtin University","startDate":"2026-04","conditions":"Uncomplicated Malaria","enrollment":60},{"nctId":"NCT05788094","phase":"PHASE4","title":"ACT vs CQ With Tafenoquine for P. Vivax Mono-infection","status":"RECRUITING","sponsor":"Shoklo Malaria Research Unit","startDate":"2023-06-26","conditions":"Malaria, Malaria, Vivax, Plasmodium Vivax Malaria","enrollment":606},{"nctId":"NCT02802501","phase":"PHASE3","title":"Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2018-04-08","conditions":"Malaria, Vivax","enrollment":150},{"nctId":"NCT02184637","phase":"PHASE1","title":"A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-07-31","conditions":"Malaria, Vivax","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tafenoquine plus DHA-Piperaquine","genericName":"Tafenoquine plus DHA-Piperaquine","companyName":"Menzies School of Health Research","companyId":"menzies-school-of-health-research","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses tafenoquine to eliminate dormant malaria parasites in the liver and piperaquine (in DHA-piperaquine) to kill active blood-stage parasites, providing both curative and preventive antimalarial activity. Used for Plasmodium vivax malaria treatment and relapse prevention, Plasmodium ovale malaria treatment and relapse prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}