{"id":"tafenoquine-plus-artesunate-pyronaridine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tafenoquine is an 8-aminoquinoline that acts on hypnozoites (dormant forms) in the liver and prevents transmission by targeting gametocytes. Artesunate-pyronaridine is a fixed-dose artemisinin-based combination that rapidly reduces parasitemia by generating reactive oxygen species and disrupting parasite metabolism. Together, they provide both rapid symptom relief and prevention of relapse and transmission.","oneSentence":"This combination targets malaria parasites through two complementary mechanisms: tafenoquine eliminates dormant liver-stage parasites and gametocytes, while artesunate-pyronaridine rapidly kills blood-stage parasites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:38:31.004Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum or Plasmodium vivax"}]},"trialDetails":[{"nctId":"NCT07060794","phase":"PHASE4","title":"Tafenoquine and ACTs (TADORE- Plus)","status":"NOT_YET_RECRUITING","sponsor":"Menzies School of Health Research","startDate":"2026-06","conditions":"Vivax Malaria","enrollment":507}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tafenoquine plus Artesunate-pyronaridine","genericName":"Tafenoquine plus Artesunate-pyronaridine","companyName":"Menzies School of Health Research","companyId":"menzies-school-of-health-research","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination targets malaria parasites through two complementary mechanisms: tafenoquine eliminates dormant liver-stage parasites and gametocytes, while artesunate-pyronaridine rapidly kills blood-stage parasites. Used for Uncomplicated malaria caused by Plasmodium falciparum or Plasmodium vivax.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}