{"id":"tafamidis-61-mg-free-acid-capsule-reference","brandName":"Tafamidis 61 mg free acid capsule (Reference)","genericName":"tafamidis-61-mg-free-acid-capsule-reference","companyId":"pfizer","companyName":"Pfizer Inc.","phase":"phase_1","status":"active","modality":"","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Tafamidis 61 mg free acid capsule is a transthyretin (TTR) stabilizer developed by Pfizer for treating transthyretin amyloidosis, a rare progressive neurodegenerative disease. The drug works by binding to and stabilizing the TTR protein, preventing its misfolding and aggregation into amyloid fibrils that damage nerves and organs. This formulation represents a Phase 1 development candidate being evaluated for bioavailability and pharmacokinetic properties compared to alternative formulations. The reference free acid capsule is part of Pfizer's formulation optimization strategy to improve drug delivery and patient tolerability. Tafamidis has established commercial significance in the rare disease space, with the approved meglumine salt formulation (Vyndaqel) generating substantial revenue. This free acid capsule development reflects ongoing efforts to optimize the therapeutic profile and potentially expand market access in transthyretin amyloidosis.","enrichmentLevel":5,"visitCount":4,"mechanism":{"target":"TTR","drugClass":"Transthyretin stabilizer","explanation":"Tafamidis works by binding to and stabilizing the transthyretin protein, which prevents it from misfolding and forming harmful amyloid deposits in the heart and nerves.","oneSentence":"Tafamidis stabilizes transthyretin, preventing amyloid formation and deposition in tissues."},"administration":{},"safety":{},"trials":[],"indications":{"approved":[],"pipeline":[],"offLabel":[]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":2,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:54:41.167769+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}