{"id":"tacrollimus-topical","safety":{"commonSideEffects":[{"rate":"10-50","effect":"Burning or stinging sensation at application site"},{"rate":"5-20","effect":"Pruritus"},{"rate":"5-15","effect":"Erythema"},{"rate":"1-5","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2108694","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tacrolimus binds to the immunophilin FKBP12 and inhibits calcineurin phosphatase, preventing dephosphorylation and nuclear translocation of NFAT (nuclear factor of activated T cells). This blocks the production of IL-2 and other cytokines essential for T-cell proliferation. When applied topically, it reduces local immune-mediated inflammation in the skin without systemic immunosuppression.","oneSentence":"Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation and proliferation by blocking the transcription of pro-inflammatory cytokines.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:54.978Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atopic dermatitis (eczema)"},{"name":"Vitiligo"},{"name":"Lichen planus"},{"name":"Other inflammatory skin conditions"}]},"trialDetails":[{"nctId":"NCT06362005","phase":"PHASE4","title":"The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2024-05-01","conditions":"Lichen Planus, Oral","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Group II"],"phase":"marketed","status":"active","brandName":"Tacrollimus Topical","genericName":"Tacrollimus Topical","companyName":"Al-Azhar University","companyId":"al-azhar-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tacrolimus Topical is a topical treatment that has been studied for the condition Oral Lichen Planus. The exact mechanism of action of Tacrolimus Topical is unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}