{"id":"tachosil-fibrin-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Seroma formation"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The patch consists of a collagen fleece coated with fibrinogen and thrombin. When applied to a bleeding surface, the thrombin activates the fibrinogen to form fibrin, which polymerizes and creates a stable clot. The collagen substrate provides structural support and enhances platelet adhesion and aggregation, accelerating hemostasis at the site of application.","oneSentence":"TachSil is a fibrin-coated collagen patch that promotes hemostasis by providing a scaffold for clot formation and delivering fibrinogen and thrombin to the wound site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:37:21.230Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis support in surgical bleeding during general, cardiac, and vascular surgery"},{"name":"Bleeding control in liver resection and other parenchymal organ surgery"}]},"trialDetails":[{"nctId":"NCT05385952","phase":"NA","title":"GATT-Patch Versus TachoSil in Liver Surgery","status":"COMPLETED","sponsor":"GATT Technologies BV","startDate":"2022-08-04","conditions":"Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases","enrollment":132},{"nctId":"NCT04660721","phase":"PHASE1, PHASE2","title":"A Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic Surgery","status":"COMPLETED","sponsor":"Sealantium Medical Ltd.","startDate":"2021-05-12","conditions":"Hemostasis, General Surgery","enrollment":33},{"nctId":"NCT06124209","phase":"PHASE4","title":"Use of Fibrin Sealant Patch for Vein Anastomosis During Deceased Donor Liver Transplantation- Randomized Clinical Trial","status":"UNKNOWN","sponsor":"Medical University of Warsaw","startDate":"2023-11-04","conditions":"Liver Transplant; Complications","enrollment":170},{"nctId":"NCT04065880","phase":"NA","title":"Neoveil® Versus TachoSil® for the Treatment of Pulmonary Air Leaks Following Lung Operation","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2020-04-01","conditions":"Prolonged Air Leak, Postoperative Air Leak","enrollment":46},{"nctId":"NCT01470677","phase":"PHASE3","title":"Tachosil for the Prevention of Symptomatic Lymph Cysts","status":"COMPLETED","sponsor":"Ruhr University of Bochum","startDate":"2011-11","conditions":"Endometrial Cancer, Cervical Cancer","enrollment":220},{"nctId":"NCT03269955","phase":"PHASE4","title":"The Effect of Application of TachoSil® in Pancreatoduodenectomy","status":"UNKNOWN","sponsor":"Asan Medical Center","startDate":"2017-02-27","conditions":"Pancreatic Neoplasm, Pancreatic Periampullary Cancer, Pancreatic Bordeline Tumor","enrollment":126},{"nctId":"NCT01500135","phase":"PHASE3","title":"Comparison of Efficacy and Safety of TachoSil® Versus Surgicel® Original for the Secondary Hemostatic Treatment of Needle Hole Bleeding in Vascular Surgery","status":"COMPLETED","sponsor":"Takeda","startDate":"2012-03","conditions":"Bleeding","enrollment":150},{"nctId":"NCT01324349","phase":"NA","title":"Comparison of the Hemostatic Patch to Fibrin Sealant (TachoSil®) in Subjects Undergoing Hepatic Surgery","status":"COMPLETED","sponsor":"Medtronic - MITG","startDate":"2011-02","conditions":"Liver Disease","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":21,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["EU registration number: EU/1/04/277/002"],"phase":"phase_3","status":"active","brandName":"Tachosil fibrin patch","genericName":"Tachosil fibrin patch","companyName":"Ruhr University of Bochum","companyId":"ruhr-university-of-bochum","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TachSil is a fibrin-coated collagen patch that promotes hemostasis by providing a scaffold for clot formation and delivering fibrinogen and thrombin to the wound site. Used for Hemostasis support in surgical bleeding during general, cardiac, and vascular surgery, Bleeding control in liver resection and other parenchymal organ surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}