{"id":"tacalcitol","rwe":[{"pmid":"40894304","year":"2025","title":"Calcitriol and Tacalcitol Modulate Th17 Differentiation Through Osteopontin Receptors: Age-Dependent Insights from a Mouse Breast Cancer Model.","finding":"","journal":"ImmunoTargets and therapy","studyType":"Clinical Study"},{"pmid":"40117094","year":"2025","title":"Molecular insights of vitamin D receptor SNPs and vitamin D analogs: a novel therapeutic avenue for vitiligo.","finding":"","journal":"Molecular diversity","studyType":"Clinical Study"},{"pmid":"38230424","year":"2024","title":"Comparison of various excimer laser (EL) combination therapies for vitiligo: a systematic review and network meta-analysis.","finding":"","journal":"The Journal of dermatological treatment","studyType":"Clinical Study"},{"pmid":"37830601","year":"2023","title":"Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review.","finding":"","journal":"Cells","studyType":"Clinical Study"},{"pmid":"37745732","year":"2023","title":"Noncorticosteroid Topical Therapies for the Treatment of Plaque Psoriasis: A Narrative Review.","finding":"","journal":"The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians","studyType":"Clinical Study"}],"tags":[{"label":"tacalcitol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Vitamin D3 receptor","category":"target"},{"label":"VDR","category":"gene"},{"label":"D05AX04","category":"atc"},{"label":"Active","category":"status"},{"label":"Plaque psoriasis","category":"indication"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Dermatologic Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["tacalcitol"],"offLabel":[],"synonyms":["tacalcitol"],"timeline":[],"approvals":[],"ecosystem":[{"indication":"Plaque psoriasis","otherDrugs":[{"name":"adalimumab","slug":"adalimumab","company":"Abbvie Inc"},{"name":"alclometasone dipropionate","slug":"alclometasone-dipropionate","company":""},{"name":"alefacept","slug":"alefacept","company":"Astellas"},{"name":"amcinonide","slug":"amcinonide","company":"Astellas"}],"globalPrevalence":125000000}],"mechanism":{"target":"Vitamin D3 receptor","targets":[{"gene":"VDR","source":"DrugCentral","target":"Vitamin D3 receptor","protein":"Vitamin D3 receptor"}],"modality":"Small Molecule","drugClass":"tacalcitol","explanation":"Think of it like a key fitting into a lock. TACALCITOL is the key that fits into the Vitamin D3 receptor lock, which helps to turn off the signals that cause inflammation and skin cell growth. This helps to reduce the symptoms of plaque psoriasis, such as redness and scaling.","oneSentence":"TACALCITOL works by binding to the Vitamin D3 receptor, which helps to reduce inflammation and modulate the immune response.","technicalDetail":"TACALCITOL acts as a selective agonist of the Vitamin D3 receptor, which activates the transcription of genes involved in the regulation of cell growth and differentiation, leading to a reduction in inflammation and an improvement in skin symptoms."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4727","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TACALCITOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TACALCITOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:47:23.770361","biosimilars":[],"competitors":[{"drugName":"calcipotriene","drugSlug":"calcipotriene","fdaApproval":"1993-12-29","patentExpiry":"May 7, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"calcitriol","drugSlug":"calcitriol","fdaApproval":"1978-08-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tazarotene","drugSlug":"tazarotene","fdaApproval":"1997-06-13","patentExpiry":"May 11, 2038","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ulobetasol propionate","drugSlug":"ulobetasol-propionate","fdaApproval":"1990-12-17","relationship":"same-class"}],"genericName":"tacalcitol","indications":{"approved":[{"name":"Plaque psoriasis","source":"DrugCentral","snomedId":200965009,"regulator":"FDA","usPrevalence":7500000,"globalPrevalence":125000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"calcipotriene","brandName":"calcipotriene","genericName":"calcipotriene","approvalYear":"1993","relationship":"same-class"},{"drugId":"calcitriol","brandName":"calcitriol","genericName":"calcitriol","approvalYear":"1978","relationship":"same-class"},{"drugId":"tazarotene","brandName":"tazarotene","genericName":"tazarotene","approvalYear":"1997","relationship":"same-class"},{"drugId":"ulobetasol-propionate","brandName":"ulobetasol propionate","genericName":"ulobetasol propionate","approvalYear":"1990","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT00670241","phase":"PHASE3","title":"Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel Compared With Tacalcitol Ointment and the Gel Vehicle Alone in Patients With Psoriasis Vulgaris","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2008-04","conditions":["Psoriasis Vulgaris"],"enrollment":458,"completionDate":"2009-04"},{"nctId":"NCT00640822","phase":"PHASE3","title":"Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment Compared With Tacalcitol Ointment in Patients With Psoriasis on the Face and Skin Folds","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2008-02","conditions":["Psoriasis Vulgaris"],"enrollment":782,"completionDate":"2009-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005930","UNII":"C2W72OJ5ZU","CHEBI":"CHEBI:32176","INN_ID":"6822","RXNORM":"291204","UMLSCUI":"C0953467","ChEMBL_ID":"CHEMBL2105611","KEGG_DRUG":"D08554","DRUGBANK_ID":"DB13689","PUBCHEM_CID":"5283734","SNOMEDCT_US":"332214000","IUPHAR_LIGAND_ID":"2780","MESH_SUPPLEMENTAL_RECORD_UI":"C023850"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":181,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"D05AX04","allCodes":["D05AX04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"40894304","title":"Calcitriol and Tacalcitol Modulate Th17 Differentiation Through Osteopontin Receptors: Age-Dependent Insights from a Mouse Breast Cancer Model.","journal":"ImmunoTargets and therapy"},{"date":"2025 Dec","pmid":"40117094","title":"Molecular insights of vitamin D receptor SNPs and vitamin D analogs: a novel therapeutic avenue for vitiligo.","journal":"Molecular diversity"},{"date":"2024 Dec","pmid":"38230424","title":"Comparison of various excimer laser (EL) combination therapies for vitiligo: a systematic review and network meta-analysis.","journal":"The Journal of dermatological treatment"},{"date":"2023 Sep 30","pmid":"37830601","title":"Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review.","journal":"Cells"},{"date":"2023 Oct","pmid":"37745732","title":"Noncorticosteroid Topical Therapies for the Treatment of Plaque Psoriasis: A Narrative Review.","journal":"The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"TACALCITOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tacalcitol is a small molecule with the synonyms 1.ALPHA.,24-DIHYDROXYVITAMIN D3, BONALFA, CURATODERM, TACALCITOL. It is being studied as a treatment for Psoriasis Vulgaris in clinical trials, including a Phase 3 study comparing it to calcipotriol plus betamethasone dipropionate gel.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}