{"id":"tac-alternate-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or erythema"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Systemic toxicity (if absorbed in large amounts)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The gel works by blocking sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses in the area where it is applied. This produces local anesthesia and reduces pain sensation. TAC (tetracaine, adrenaline/epinephrine, cocaine) formulations have been used in emergency medicine and minor surgical procedures, though the 'alternate' formulation likely refers to a modified composition, possibly substituting cocaine with safer alternatives like lidocaine or prilocaine.","oneSentence":"TAC alternate gel is a topical anesthetic formulation combining lidocaine, prilocaine, and other agents to provide local pain relief and numbing at the site of application.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:10:46.782Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for minor wounds and lacerations"},{"name":"Topical pain relief for minor surgical procedures"}]},"trialDetails":[{"nctId":"NCT04469075","phase":"PHASE2","title":"Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2020-07-09","conditions":"Glioblastoma, Recurrent Glioblastoma, Skin Toxicity","enrollment":48},{"nctId":"NCT00846690","phase":"PHASE4","title":"Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel","status":"UNKNOWN","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2009-01","conditions":"Dental Pain, Postoperative Pain","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["20% TAC alternate gel"],"phase":"marketed","status":"active","brandName":"TAC alternate gel","genericName":"TAC alternate gel","companyName":"The University of Texas Health Science Center, Houston","companyId":"the-university-of-texas-health-science-center-houston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TAC alternate gel is a topical anesthetic formulation combining lidocaine, prilocaine, and other agents to provide local pain relief and numbing at the site of application. Used for Local anesthesia for minor wounds and lacerations, Topical pain relief for minor surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}