{"id":"systane-r-ultra","safety":{"commonSideEffects":[{"rate":null,"effect":"Eye irritation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Ocular discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Systane Ultra contains a proprietary blend of lubricants including polyethylene glycol 400 and propylene glycol, along with the gelling agent hydroxypropyl guar, which creates a sustained-release formulation. The formula adheres to the eye surface and provides long-lasting lubrication and protection for dry eye symptoms. It works through mechanical hydration and surface protection rather than targeting a specific molecular receptor.","oneSentence":"Systane Ultra is a lubricating eye drop that provides sustained moisture and relief to the ocular surface by forming a protective film.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:40.869Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye syndrome / dry eye disease"}]},"trialDetails":[{"nctId":"NCT02985827","phase":"PHASE4","title":"Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra)","status":"COMPLETED","sponsor":"ORA, Inc.","startDate":"2015-12","conditions":"Dry Eye","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Systane Ultra"],"phase":"marketed","status":"active","brandName":"Systane (r) Ultra","genericName":"Systane (r) Ultra","companyName":"ORA, Inc.","companyId":"ora-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Systane Ultra is a lubricating eye drop that provides sustained moisture and relief to the ocular surface by forming a protective film. Used for Dry eye syndrome / dry eye disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}