{"id":"syntommetrine-and-carbetocin","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Uterine cramping"},{"rate":null,"effect":"Coronary vasospasm (ergot-containing formulations)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Syntommetrine combines ergotamine (which causes sustained uterine contraction) with oxytocin (which triggers rhythmic contractions). Carbetocin is a synthetic oxytocin analogue with longer duration of action and greater stability. Both work by binding oxytocin receptors on uterine smooth muscle, promoting sustained contraction to compress bleeding vessels and control hemorrhage after delivery.","oneSentence":"Syntommetrine (ergot alkaloid + oxytocin combination) and Carbetocin (oxytocin analogue) stimulate uterine muscle contraction to prevent or treat postpartum hemorrhage.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:37.223Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of postpartum hemorrhage"},{"name":"Active management of the third stage of labor"}]},"trialDetails":[{"nctId":"NCT00499005","phase":"PHASE4","title":"Carbetocin Versus Syntometrine for the Third Stage of Labour","status":"COMPLETED","sponsor":"National University Hospital, Singapore","startDate":"2006-11","conditions":"Postpartum Haemorrhage","enrollment":720}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Syntommetrine and Carbetocin","genericName":"Syntommetrine and Carbetocin","companyName":"National University Hospital, Singapore","companyId":"national-university-hospital-singapore","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Syntommetrine (ergot alkaloid + oxytocin combination) and Carbetocin (oxytocin analogue) stimulate uterine muscle contraction to prevent or treat postpartum hemorrhage. Used for Prevention and treatment of postpartum hemorrhage, Active management of the third stage of labor.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}