{"id":"synovian-inj","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Transient joint effusion"},{"rate":null,"effect":"Local inflammation"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Synovian works by supplementing the synovial fluid in affected joints with hyaluronic acid, a naturally occurring polysaccharide that provides viscosity and elasticity to joint fluid. This restores the lubricating and shock-absorbing properties of the joint, reducing friction between cartilage surfaces and alleviating pain associated with osteoarthritis. The treatment is administered directly into the joint space for localized therapeutic effect.","oneSentence":"Synovian is a hyaluronic acid-based intra-articular injection that lubricates and cushions joint cartilage to reduce pain and improve mobility in osteoarthritis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:37:06.672Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee"},{"name":"Osteoarthritis of other joints (hip, shoulder, ankle)"}]},"trialDetails":[{"nctId":"NCT06399042","phase":"PHASE3","title":"Pivotal Study to Evaluate Efficacy and Safety of SP5M002 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Shin Poong Pharmaceutical Co. Ltd.","startDate":"2023-06-14","conditions":"Osteoarthritis","enrollment":297},{"nctId":"NCT06307847","phase":"PHASE3","title":"Pivotal Study to Evaluate Efficacy and Safety of SP5M001 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis","status":"COMPLETED","sponsor":"Shin Poong Pharmaceutical Co. Ltd.","startDate":"2021-04-14","conditions":"Osteoarthritis Thumb","enrollment":223},{"nctId":"NCT03561779","phase":"PHASE3","title":"Clinical Trial of YYD302 (Phase3) for Treatment of Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Yooyoung Pharmaceutical Co., Ltd.","startDate":"2018-02-21","conditions":"Osteoarthritis, Knee","enrollment":184},{"nctId":"NCT04369261","phase":"","title":"Observational Study of Synovian® Inj. in Patients With Osteoarthritis in the Knee","status":"COMPLETED","sponsor":"LG Chem","startDate":"2018-03-09","conditions":"Osteoarthritis in the Knee","enrollment":1949}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Synovian inj","genericName":"Synovian inj","companyName":"Shin Poong Pharmaceutical Co. Ltd.","companyId":"shin-poong-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Synovian is a hyaluronic acid-based intra-articular injection that lubricates and cushions joint cartilage to reduce pain and improve mobility in osteoarthritis. Used for Osteoarthritis of the knee, Osteoarthritis of other joints (hip, shoulder, ankle).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}